System containing ingestible ultrasound device for delivery of therapeutic agents

A system comprising:

• a transmitter comprising:
• a power source;
• and
• a transmitter coil electrically coupled to the power source;
• and
• an ingestible capsule that is physically separate from the transmitter, the ingestible capsule comprising:
• an inductive receiver coil configured to receive an electromagnetic signal from the transmitter when the transmitter is not in contact with the ingestible capsule;
• an ultrasound transducer electrically coupled to the inductive receiver;
• and
• a reservoir configured to releasably retain a liquid comprising a therapeutic agent.

A method of administering a therapeutic agent to a gastrointestinal tissue of a subject, the method comprising:

• orally administering to a subject an ingestible capsule that does not comprise a power source, the capsule comprising:
• an inductive receiver coil;
• an ultrasound transducer electrically coupled to the inductive receiver;
• and
• a reservoir comprising a liquid comprising a therapeutic agent, and
• transmitting via a transmitter external to the subject an electromagnetic signal to the ingestible capsule to allow the ultrasound transducer to generate an ultrasound signal and thereby deliver the therapeutic agent from the reservoir into gastrointestinal tissue of the subject.