# US 2024/0197976 A1 · Blood plasma separation device

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- Number: US 2024/0197976 A1
- Document ID: US20240197976A1
- Status: Published application
- Kind: A1
- Application number: 18/589,278
- Filed: 2024-02-27
- Published: 2024-06-20
- Earliest claimed: 2018-08-23
- Assignees: Truvian Sciences, Inc.
- Applicants: Truvian Sciences, Inc.
- Inventors: Ian Kleinemolen; Dena Marrinucci; Kameel Michael Abi-Samra
- Web page: https://patentgrep.com/patent/US20240197976A1

## CPC

- A61M 1/3496: {Plasmapheresis; Leucopheresis; Lymphopheresis (A61M1/3472 takes precedence)}
- A61M 1/3693: {using separation based on different densities of components, e.g. centrifuging}
- B01L 3/502: {with fluid transport, e.g. in multi-compartment structures}
- B01L 3/50273: {characterised by the means or forces applied to move the fluids}
- B01L 3/502746: {characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves}
- G01N 33/491: {by separating the blood components (G01N15/05 takes precedence)}
- G01N 33/5002: {Partitioning blood components}
- A61M 1/3472: {with treatment of the filtrate}
- B01L 2200/0621: Control of the sequence of chambers filled or emptied
- B01L 2300/0803: Disc shape
- B01L 2300/0816: Cards, e.g. flat sample carriers usually with flow in two horizontal directions
- B01L 2300/0864: comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
- B01L 2400/0409: centrifugal forces
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A device for separating blood plasma from whole blood includes a first reservoir and a second reservoir. The first reservoir is configured to receive a sample of whole blood including red blood cells and includes a collection region and a constricted region. The second reservoir is fluidically connected to the constricted region of the first reservoir, such that, responsive to centrifugal force applied to the device, the sample of whole blood disposed within the first reservoir separates into a first fraction and a second fraction. The first fraction is located in the collection region and includes blood plasma from which substantially all red blood cells have been removed. The second fraction is located in the second reservoir and includes blood plasma and red blood cells that have been removed from the first fraction by the centrifugal force. The constricted region inhibits the second fraction from entering the collection region.

## Claims

### Claim 1

A device for separating blood plasma from whole blood comprising a first reservoir and a second reservoir, the second reservoir fluidically connected to the first reservoir, the first reservoir comprising a collection region and a channel fluidly connected to the collection region, the collection region comprising a first fraction of whole blood the first fraction comprising blood plasma from which substantially all red blood cells have been removed, the channel comprising the first fraction, the second reservoir comprises a second fraction of the whole blood the second fraction comprising blood plasma and the red blood cells that have been removed from the first fraction.

### Claim 2 (depends on 1)

The device of claim 1, wherein the channel is configured to substantially fill with the first fraction via capillary action responsive to termination of a centrifugal force.

### Claim 3 (depends on 1)

The device of claim 1, wherein an optically transparent cover is disposed over the first reservoir and second reservoir.

### Claim 4 (depends on 1)

The device of claim 1, wherein the channel comprises an outlet.

### Claim 5 (depends on 1)

The device of claim 1, further comprising a constricted region configured to inhibit the second fraction from entering the collection region.

### Claim 6 (depends on 1)

The device of claim 1, wherein the second reservoir is fluidly connected to the first reservoir by a constriction region.

### Claim 7

A device for separating blood plasma from whole blood comprising a first reservoir and a second reservoir, the second reservoir fluidically connected to the first reservoir, the first reservoir comprising a collection region and a channel fluidly connected to the collection region, the collection region comprising whole blood at a first time point, the channel and second reservoir are empty at the first time point, the collection region comprising a first fraction of the whole blood the first fraction comprising blood plasma and less than 25% red blood cells at a second time point, the channel comprising the first fraction at the second time point.

### Claim 8 (depends on 7)

The device of claim 7, wherein a centrifugal force is applied to the device between the first time point and the second time point.

### Claim 9 (depends on 7)

The device of claim 7, wherein at a third time point the first reservoir is empty.

### Claim 10

A device for separating blood plasma from whole blood comprising a first reservoir and a second reservoir, the second reservoir fluidically connected to the first reservoir, the first reservoir comprising a collection region and a channel fluidly connected to the collection region, the collection region comprising whole blood at a first time point, the channel and second reservoir are empty at the first time point, the collection region comprising at a second time point a first fraction of the whole blood the first fraction comprising blood plasma and less than 25% red blood cells, the channel comprising the first fraction at the second time point, the second reservoir comprises at a second time point a second fraction of the whole blood the second fraction comprising blood plasma and red blood cells.

### Claim 11 (depends on 10)

The device of claim 10, wherein at a third time point the first reservoir is empty.

### Claim 12 (depends on 10)

The device of claim 10, wherein the red blood cells are in a pellet in the second reservoir.

### Claim 13 (depends on 10)

The device of claim 10, wherein at a third time point the first fraction is removed from the first reservoir via an outlet in the channel.

### Claim 14 (depends on 10)

The device of claim 10, wherein the channel is disposed at an acute angle relative to the collection region.

### Claim 15 (depends on 10)

The device of claim 10, wherein the first fraction substantially fills the first reservoir.

### Claim 16 (depends on 10)

The device of claim 10, wherein the device sits radially on a disk.

### Claim 17 (depends on 10)

The device of claim 10, wherein a meniscus of the blood plasma is within the first reservoir.

### Claim 18 (depends on 10)

The device of claim 10, wherein the volume of the second reservoir is less than the volume of the first reservoir.

### Claim 19 (depends on 10)

The device of claim 10, wherein at least 99% of the red blood cells in the sample of whole blood are removed from the first fraction.

### Claim 20 (depends on 10)

The device of claim 10, wherein the channel is substantially filed with the first fraction.