System and method for allogeneic or xenogeneic use of alpha 2m molecules in treating medical conditions

A kit for treating a respiratory condition of a patient with Alpha-2 Macroglobulin (α2M) molecules in an allogeneic or xenogeneic manner, the kit comprising:

• at least one separator tube, wherein each separator tube of the at least one separator tube comprises:
• an elongate transparent tube that defines an opening at one end that is sealed with a cap that is penetrable to receive whole blood drawn from a donor;
• and
• an amount of separator gel disposed within the separator tube to cooperate with a first centrifugal force exerted on the separator tube for a first period of time during a first centrifuging stage to separate plasma containing α2M molecules from other components of the whole blood;
• at least one isolator, wherein each isolator of the at least one isolator comprises:
• a filter;
• a first cylinder defined by a first cylindrical wall having a first end that is configured to be closable with a septum cap that is penetrable to receive the plasma containing the α2M molecules following the first centrifuging stage, and having a second end that is closed with the filter;
• and
• a second cylinder defined by a second cylindrical wall having a first end that is closed where the second cylindrical wall narrows to form a conically-shaped end portion, and having a second end that defines an opening that is configured to be coupled to the filter in a manner that causes a first interior space of the first cylinder and a second interior space of the second cylinder to be separated by the filter, wherein:
• the filter is configured to cooperate with a second centrifugal force exerted on the isolator for a second period of time during a second centrifuging stage to isolate the α2M molecules from other components of the plasma in preparation for administering the isolated α2M molecules to the patient;
• and
• a transfer device, comprising:
• a separator tube port configured to receive each separator tube of the at least one separator tube, one at a time, wherein the separator tube port comprises at least one hollow needle configured to penetrate the cap of each separator tube to couple the separator tube to a syringe port of the transfer device;
• and
• a syringe port configured to receive an end connector of a transfer syringe that is configured to be coupled to a transfer needle, wherein, following the first centrifuging stage and prior to the second centrifuging stage:
• while each separator tube of the at least one separator tube is coupled to the separator tube port, a plunger of the transfer syringe is operable to withdraw at least some of the plasma from within the separator tube and into the transfer syringe through the transfer device;
• and
• following transfer of plasma from each separator tube of the at least one separator tube, and with the transfer needle coupled to the end connector to penetrate the septum cap of each isolator of the at least one isolator, the plunger of the transfer syringe is operable to inject the plasma within the transfer syringe into the at least one isolator.