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US 2024/0197858 A1Published application
Nipah virus immunogens and their use
AssigneeThe USA, as represented by the Secretary, Department of Health and Human Service
InventorsBarney Graham, Rebecca Loomis, Guillaume Stewart-Jones, John Mascola
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Abstract
Embodiments of immunogens comprising a multimer of NiV G ectodomains and protein nanoparticles comprising an NiV G ectodomain are provided. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits NiV infection in a subject.
Claims19
An immunogen, comprising:
- a trimer of fusion proteins, each fusion protein comprising, in an N- to C-terminal direction:
- one or more NiV G ectodomains and a trimerization domain;
- a trimerization domain and one or more NiV G ectodomains;
- or
- one or more NiV G ectodomains, a trimerization domain, and one or more NiV G ectodomains;
- and wherein the trimerization domains interact to form the trimer;
- or
- a protein nanoparticle comprising one or more NiV G ectodomains extending radially outward from a globular surface of the nanoparticle, the protein nanoparticle comprising self-assembling protein nanoparticle subunits, wherein each subunit is fused N-terminally to the one or more NiV G ectodomain.
5 more elements
An immunogen, comprising:
- a protein nanoparticle comprising one or more NiV G ectodomains extending radially outward from a globular surface of the nanoparticle, the protein nanoparticle comprising self-assembling protein nanoparticle subunits, wherein each subunit is fused N-terminally to one or more NiV G ectodomains.
Dependencies are inferred from the claim text.