# US 2024/0197650 A1 · Combination of Cinnamaldheyde and Eugenol with Antimycotic Activity

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2024/0197650 A1
- Document ID: US20240197650A1
- Status: Published application
- Kind: A1
- Application number: 18/288,840
- Filed: 2022-06-28
- Published: 2024-06-20
- Earliest claimed: 2021-06-29
- Assignees: Targeting Gut Disease Srl
- Applicants: Targeting Gut Disease Srl
- Inventors: Maria Chiara VALERII
- Web page: https://patentgrep.com/patent/US20240197650A1

## CPC

- A61K 31/11: Aldehydes
- A61K 31/085: having an ether linkage to aromatic ring nuclear carbon
- A61K 36/54: Lauraceae (Laurel family), e.g. cinnamon or sassafras
- A61K 36/61: Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
- A61P 31/10: Antimycotics
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A combination of active ingredients of plant origin or synthetic analogues or extracts of plant origin containing cinnamaldheyde and eugenol or derivatives thereof, useful as antimycotic for both human and veterinary therapeutic use, mainly against fungal infections caused by Candida. Compositions containing the combination for topical or systemic administration are also described.

## Claims

### Claim at position 1

1: A combination of cinnamaldehyde and eugenol for use as antimycotic in humans and animals for the treatment of fungal infections caused by Candida, without affecting the growth of Lactobacillus acidophilus, wherein cinnamaldehyde and eugenol are in a ratio ranging from 1:1 to 1:10 w/w.

### Claim at position 2 (depends on 1)

2: A composition containing the combination according to claim 1 in admixture with a suitable carrier for topical or systemic administration.

### Claim at position 3 (depends on 1)

3: A combination according to claim 1 wherein the daily dose of cinnamaldehyde ranges from 0.03 mg/kg to 300 mg/kg and the daily dose of eugenol ranges from 0.03 mg/kg to 300 mg/kg.

### Claim at position 4 (depends on 1)

4: A combination according to claim 1 wherein the cinnamaldehyde:eugenol ratio is 1:2 w/w.

### Claim at position 5 (depends on 1)

5: A combination according to claim 1 wherein cinnamaldehyde and eugenol are used in the form of essential oils.

### Claim at position 6 (depends on 5)

6: A combination according to claim 5 wherein the essential oils are selected from cinnamon essential oil and clove essential oil.

### Claim at position 7 (depends on 1)

7: A combination according to claim 1 wherein cinnamaldehyde and eugenol are used in purified form.

### Claim at position 8 (depends on 1)

8: A combination according to claim 1 for use against fungal infections caused by Candida, wherein the fungal infections are candidosis or thrush.

### Claim at position 9

9: A method of treating fungal infections caused by Candida, comprising the step of administering a combination of cinnamaldehyde and eugenol to treat a fungal infection of a human or animal, wherein the cinnamaldehyde and eugenol are in a ratio ranging from 1:1 to 1:10 w/w.

### Claim at position 10 (depends on 9)

10: The method according to claim 9, wherein the combination is contained within in a composition of a mixture of the combination with a carrier and said administering step is provided by topical or systemic administration.

### Claim at position 11 (depends on 9)

11: The method according to claim 9, wherein said administering step includes a daily dose of cinnamaldehyde ranging from 0.03 mg/kg to 300 mg/kg and a daily dose of eugenol from 0.03 mg/kg to 300 mg/kg.

### Claim at position 12 (depends on 9)

12: The method according to claim 9, wherein the cinnamaldehyde:eugenol ratio is 1:2 w/w.

### Claim at position 13 (depends on 9)

13: The method according to claim 9, wherein the cinnamaldehyde and eugenol are in the form of essential oils.

### Claim at position 14 (depends on 13)

14: The method according to claim 13, wherein the essential oils are selected from cinnamon essential oil and clove essential oil.

### Claim at position 15 (depends on 9)

15: The method according to claim 9, wherein the cinnamaldehyde and eugenol are in purified form.

### Claim at position 16 (depends on 9)

16: The method according to claim 9, wherein the fungal infections are candidosis or thrush.