# US 2024/0197648 A1 · Substrate for delivering a biologically active substance > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2024/0197648 A1 - Document ID: US20240197648A1 - Status: Published application - Kind: A1 - Application number: 18/285,550 - Filed: 2022-04-13 - Published: 2024-06-20 - Earliest claimed: 2021-04-15 - Assignees: Philip Morris Products S.A. - Applicants: Philip Morris Products S.A. - Inventors: Mari Liova Atabekyan; Zoya Melik Farmazyan; Stepan Grigor Grigoryan; Laurent Lavanant; Vigen Onik Topuzyan - Web page: https://patentgrep.com/patent/US20240197648A1 ## CPC - A61K 9/7084: {Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches} - A24B 15/32: by acyclic compounds - A61K 9/007: {Pulmonary tract; Aromatherapy} - A61K 9/146: {with organic macromolecular compounds} - A61K 31/196: the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil - A61K 31/24: having an amino or nitro group - A61K 31/422: not condensed and containing further heterocyclic rings - A61K 31/435: having six-membered rings with one nitrogen as the only ring hetero atom - A61K 31/465: Nicotine; Derivatives thereof - C08K 5/05: Alcohols; Metal alcoholates - C08K 5/053: Polyhydroxylic alcohols - C08K 5/5415: containing at least one Si—O bond - C08L 83/04: Polysiloxanes - C09J 183/04: Polysiloxanes - C08G 77/16: to hydroxy groups - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A24B: MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF - C08K: Use of inorganic or non-macromolecular organic substances as compounding ingredients (paints, inks, varnishes, dyes, polishes, adhesives C09) - C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06) - C09J: ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES (preparation of glue or gelatine C09H) - C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS ## Abstract A substrate (12) for delivering a biologically active substance. the substrate (12) comprising: a cross-linked silicone matrix formed by cross-linking a silicone polymer using at least one crosslinking agent comprising a tetraalkoxysilane, the cross-linked silicone matrix defining a plurality of domains, and a composition contained within the domains of the cross-linked silicone matrix, wherein the composition comprises: at least one monomeric glycol and at least one biologically active substance. ## Claims ### Claim 1 A substrate for delivering a biologically active substance, the substrate comprising: a cross-linked silicone matrix formed by cross-linking a silicone polymer using at least one crosslinking agent comprising a tetraalkoxysilane, the cross-linked silicone matrix defining a plurality of domains; and a composition contained within the domains of the cross-linked silicone matrix, wherein the composition comprises: at least one monomeric glycol; and at least one biologically active substance. ### Claim 2 (depends on 1) A substrate according to claim 1 wherein the at least one crosslinking agent is selected from the group consisting of TEOS, silicon glycerate, and silicon 1,2-propylene glycolate. ### Claim 3 (depends on 2) A substrate according to claim 2 wherein the at least one crosslinking agent comprises one or both of silicon glycerate and silicon 1,2-propylene glycolate. ### Claim 4 (depends on 1) A substrate according to claim 1 wherein the at least one crosslinking agent is used in an amount of between about 0.2 percent and about 18 percent by weight. ### Claim 5 (depends on 1) A substrate according to claim 1 wherein the at least one monomeric glycol comprises one or both of glycerol and 1,2-propylene glycol. ### Claim 6 (depends on 1) A substrate according to claim 1 wherein the substrate comprises the at least one monomeric glycol in an amount of between about 10 percent and about 60 percent by weight. ### Claim 7 (depends on 1) A substrate according to claim 1 wherein the silicone polymer comprises a hydroxyl-terminated silicone polymer. ### Claim 8 (depends on 7) A substrate according to claim 7 wherein the silicone polymer comprises hydroxyl-terminated polydimethylsiloxane. ### Claim 9 (depends on 1) A substrate according to claim 1 wherein the silicone polymer is used in an amount of between about 35 percent and about 85 percent by weight. ### Claim 10 (depends on 1) A substrate according to claim 1 wherein the substrate comprises a curing catalyst. ### Claim 11 (depends on 10) A substrate according to claim 10 wherein the curing catalyst comprises at least one of an aminopropyl-terminated silicone polymer, an amine, and a metal-based catalyst. ### Claim 12 (depends on 10) A substrate according to claim 10 wherein the substrate comprises the curing catalyst in an amount of between about 0.2 percent and about 12 percent by weight. ### Claim 13 (depends on 1) A substrate according to claim 1 wherein the substrate comprises the at least one biologically active substance in an amount of between about 0.2 percent and about 15 percent by weight. ### Claim 14 (depends on 1) A substrate according to claim 1 wherein the at least one biologically active substance comprises nicotine. ### Claim 15 (depends on 1) An aerosol-generating article comprising a substrate according to claim 1 4. ### Claim 16 (depends on 1) A transdermal patch comprising a substrate according to claim 1. ### Claim 17 (depends on 1) An oral delivery product comprising a substrate according to claim 1.