# US 2024/0197359 A1 · Pixel array medical systems, devices and methods

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- Number: US 2024/0197359 A1
- Document ID: US20240197359A1
- Status: Published application
- Kind: A1
- Application number: 18/357,256
- Filed: 2023-07-24
- Published: 2024-06-20
- Earliest claimed: 2019-06-17
- Assignees: Srgi Holdings, LLC
- Inventors: Edward KNOWLTON
- Web page: https://patentgrep.com/patent/US20240197359A1

## CPC

- A61B 17/205: {Vaccinating by means of needles or other puncturing devices}
- A61B 17/322: Skin grafting apparatus
- A61B 17/24: for use in the oral cavity, larynx, bronchial passages or nose (for medical inspection of cavities or tubes in the body A61B1/00); Tongue scrapers
- A61B 17/320068: {using mechanical vibrations, e.g. ultrasonic (A61B17/22012 takes precedence; dental tooth drilling devices operated by vibration A61C3/03; removing intra-ocular material using mechanical vibrations A61F9/00745)}
- A61B 17/32053: {Punch like cutting instruments, e.g. using a cylindrical or oval knife (A61B17/326 takes precedence; trepans A61B17/1695)}
- A61B 17/32093: {for skin incisions}
- A61B 17/3211: Surgical scalpels, knives; Accessories therefor
- A61B 18/1487: {Trocar-like, i.e. devices producing an enlarged transcutaneous opening}
- A61B 18/1206: {Generators therefor}
- A61B 2017/00199: {with a console, e.g. a control panel with a display}
- A61B 2017/00398: {using powered actuators, e.g. stepper motors, solenoids}
- A61B 2017/00477: {Coupling (A61B2017/0046 takes precedence)}
- A61B 2017/00561: {creating a vacuum}
- A61B 2017/00747: {Dermatology}
- A61B 2017/00752: {Hair removal or transplantation}
- A61B 2017/00756: {Port wine stains}
- A61B 2017/00761: {Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue}
- A61B 2017/00769: {Tattoo removal}
- A61B 2017/00792: {Plastic surgery}
- A61B 2017/00796: {Breast surgery}
- A61B 2017/00805: {Treatment of female stress urinary incontinence}
- A61B 2017/00969: {used for transplantation}
- A61B 2017/248: {Operations for treatment of snoring, e.g. uvulopalatoplasty}
- A61B 2017/306: {holding by means of suction}
- A61B 2017/320052: {Guides for cutting instruments}
- A61B 2017/320064: {with tissue or sample retaining means}
- A61B 2017/32007: {with suction or vacuum means}
- A61B 2017/3225: {with processing of harvested tissue}
- A61B 2017/3407: {including a base for support on the body}
- A61B 2017/3409: {including needle or instrument drives}
- A61B 2018/00452: {Skin}
- A61B 2018/00458: {Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains}
- A61B 2018/00464: {Subcutaneous fat, e.g. liposuction, lipolysis}
- A61B 2018/0047: {Upper parts of the skin, e.g. skin peeling or treatment of wrinkles}
- A61B 2018/00476: {Hair follicles}
- A61B 2018/00601: {Cutting}
- A61B 2018/00994: {combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound}
- A61B 2018/1273: {including multiple generators in one device}
- A61B 2218/007: Aspiration
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

Embodiments include a method comprising determining histological factors at a target site of a subject, and determining parameters of a fractional resection based on the histological factors. The parameters include dimensionality of a fractional field, orientation of the fractional field, resection depth, and a vector of directed closure. The method includes configuring a cannula assembly for the fractional resection that includes a procedure to generate a fractional field at the target site by fractionally resecting tissue according to the parameters. The fractional resection includes applying a cannula array of the cannula assembly to the target site, and rotating at least one cannula of the cannula array to circumferentially incise and remove a plurality of skin plugs in the fractional field.

## Claims

### Claim at position 1

1-47. (canceled)

### Claim 48

A method comprising:
determining a parameter of a fractional resection based on histological factors of a subject; and
configuring a cannula assembly for the fractional resection, wherein the fractional resection includes generating a fractional field at a target site by rotating at least one cannula of the cannula assembly to circumferentially incise skin tissue in the fractional field and selectively controlling evacuation of an amount of at least one of skin tissue and fat tissue in accordance with the parameter.

### Claim 49 (depends on 48)

The method of claim 48, wherein the parameter includes at least one of dimensionality of a fractional field, orientation of the fractional field, resection depth, and a vector of directed closure.

### Claim 50 (depends on 48)

The method of claim 48, wherein histological factors include at least one of skin laxity and skin thickness.

### Claim 51 (depends on 48)

The method of claim 48, wherein the cannula assembly includes the at least one cannula configured for rotational operation and enclosed in a depth guide configured to control an insertion depth of the at least one cannula at the target site.

### Claim 52 (depends on 51)

The method of claim 51, wherein a proximal end of the cannula assembly is configured to removably couple to a carrier comprising a proximal end and a distal end, wherein the proximal end of the carrier is configured to removably couple to a motor of a remote console, and couple rotational force from the motor to the cannula assembly, wherein the at least one cannula is configured to rotate at controlled speeds around a central axis of the at least one cannula.

### Claim 53 (depends on 51)

The method of claim 51, wherein the depth guide includes a chamber configured to couple to a remote vacuum source that configures the cannula assembly to evacuate resected tissue away from the target site.

### Claim 54 (depends on 51)

The method of claim 51, wherein the at least one cannula comprises at least one scalpet including a shaft comprising a lumen, and a distal end sharpened around a circumference of the shaft and forming a cutting edge.

### Claim 55 (depends on 54)

The method of claim 54, wherein the at least one scalpet includes at least one aperture positioned axially in the shaft adjacent the lumen, wherein the lumen and the at least one aperture are configured to pass the tissue.

### Claim 56 (depends on 55)

The method of claim 55, wherein the chamber of the depth guide is configured to couple vacuum to the lumen via the aperture, wherein the vacuum is configured to evacuate the resected tissue via the lumen and the chamber.

### Claim 57 (depends on 56)

The method of claim 56, comprising a plurality of depth guides, wherein each depth guide of the plurality of depth guides corresponds to a different insertion depth, wherein the insertion depth is variable in a range of approximately 0.1 millimeters to eight (8) millimeters, wherein the depth guide is selected based on the insertion depth of the fractional resection.

### Claim 58 (depends on 48)

The method of claim 48, wherein the cannula assembly comprises a multi-scalpet array (MSA).

### Claim 59 (depends on 58)

The method of claim 58, wherein the at least one cannula includes a plurality of scalpets, and each scalpet of the plurality of scalpets comprises a shaft comprising a lumen, and a distal end sharpened around a circumference of the shaft and forming a cutting edge.

### Claim 60 (depends on 58)

The method of claim 58, wherein the MSA includes a drive shaft coupled to a proximal region of a central scalpet of the scalpet array, wherein the drive shaft is configured to couple rotational force from a remote source to the plurality of scalpets.

### Claim 61 (depends on 60)

The method of claim 60, wherein each scalpet of the scalpet array includes a gear in a proximal region of the scalpet, wherein the gears of the plurality of scalpets intermesh and the plurality of scalpets operates in unison.

### Claim 62 (depends on 61)

The method of claim 61, comprising a gearbox configured to house the gears and the proximal region of each scalpet of the plurality of scalpets.

### Claim 63 (depends on 62)

The method of claim 62, wherein the distal end, the lumen, and a proximal end of each scalpet of the plurality of scalpets is configured to pass resected tissue from a target site.

### Claim 64 (depends on 63)

The method of claim 63, wherein the MSA is configured to couple to a remote vacuum source to evacuate resected tissue of a fractional resection away from a target site via each scalpet of the plurality of scalpets.

### Claim 65 (depends on 64)

The method of claim 64, wherein vacuum is configured to remove the resected tissue from a target site by drawing the resected tissue away from the target site via the distal end, the lumen, and the proximal end of the plurality of scalpets.

### Claim 66 (depends on 58)

The method of claim 58, comprising a depth slider configured to control selection of the insertion depth of the plurality of scalpets, wherein a longitudinal position of the depth slider along the MSA controls the insertion depth by controlling a length of the plurality of scalpets extending beyond the distal end of the depth slider.

### Claim 67 (depends on 66)

The method of claim 66, wherein the depth slider is coupled to a lock collar configured to secure the depth slider in a selected position, wherein the lock collar is configured to slide along an external region of the MSA to control a state of the depth slider between a locked state and an unlocked state, wherein in the unlocked state the depth slider is free to be moved to a position corresponding to a selected insertion depth of the plurality of scalpets, and in the locked state the depth slider is secured in a selected position.

### Claim 68 (depends on 51)

The method of claim 51, wherein the at least one cannula includes a focal lipectomy cannula, wherein the focal lipectomy cannula includes a tube comprising a lumen and a distal end that is blunt around a circumference of the tube.

### Claim 69 (depends on 68)

The method of claim 68, wherein the focal lipectomy cannula includes at least one aperture positioned axially in a proximal region of the cannula adjacent the lumen, wherein the focal lipectomy cannula is configured to pass resected tissue from the target site via the lumen and the at least one aperture.