# US 2024/0197323 A1 · Medical member > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2024/0197323 A1 - Document ID: US20240197323A1 - Status: Published application - Kind: A1 - Application number: 18/587,161 - Filed: 2024-02-26 - Published: 2024-06-20 - Earliest claimed: 2021-09-03 - Assignees: Terumo Kabushiki Kaisha - Applicants: Terumo Kabushiki Kaisha - Inventors: Naoki ARAMAKI; Miho KAI; Mizuho SHIRAISHI; Miria SUZUKI - Web page: https://patentgrep.com/patent/US20240197323A1 ## CPC - A61B 17/07292: {Reinforcements for staple line, e.g. pledgets} - A61B 17/1114: {of the digestive tract, e.g. bowels or oesophagus} - A61B 2017/00004: {(bio)absorbable, (bio)resorbable or resorptive} - A61B 2017/00526: {Methods of manufacturing} - A61B 2017/00725: {Calibration or performance testing} - A61B 2017/00884: {enhancing wound closure} - A61B 2017/1132: {End-to-end connections} - A61B 2090/037: {with a frangible part, e.g. by reduced diameter} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A medical member having flexibility and strength suitable for application to anastomotic portions, and having effectively improved breaking processability. The medical member includes a mesh-like main body that promotes adhesion of the anastomotic portions, in which the main body includes a breakable portion having a relationship between a breaking strength and a compression elongation percentage, represented by the following formulas (1) to (4): Y ≤ 244734 ⁢ ( X - Z ) - 1.665 ( 1 ) 0 ≤ Z < 408.216 ( 2 ) X - Z > 0 ( 3 ) 39 ≤ X . ( 4 ) ## Claims ### Claim 1 A medical member comprising: a mesh-like main body that has a plurality of through-holes, the mesh-like main body configured to induce expression of a biological component by being applied to anastomotic portions of a biological organ, and to promote adhesion of the anastomotic portions by the induced biological component passing through the through-holes and being accumulated, wherein the main body includes, when a breaking strength of the main body in a direction intersecting with a plane direction is represented by Y, and a compression elongation percentage of the main body in the plane direction is represented by X, a breakable portion having a relationship between the breaking strength and the compression elongation percentage, represented by the following formulas (1) to (4): Y ≤ 244734 ⁢ ( X - Z ) - 1.665 ( 1 ) 0 ≤ Z < 408.216 ( 2 ) X - Z > 0 ( 3 ) 39 ≤ X . ( 4 ) ### Claim 2 (depends on 1) The medical member according to claim 1, wherein 0≤Z≤351.466 is satisfied in the formula (2). ### Claim 3 (depends on 1) The medical member according to claim 1, wherein Z=0 is satisfied in the formula (2). ### Claim 4 (depends on 1) The medical member according to claim 1, wherein the breaking strength is 16 Newtons (N) or less. ### Claim 5 (depends on 1) The medical member according to claim 1, wherein the compression elongation percentage is 1414% or less. ### Claim 6 (depends on 1) The medical member according to claim 1, wherein at least a part of the breakable portion is disposed at a position closer to a center portion of the main body in the plane direction than an outer peripheral portion of the main body. ### Claim 7 (depends on 1) The medical member according to claim 1, wherein a constituent material of the breakable portion contains polyglycolic acid. ### Claim 8 (depends on 7) The medical member according to claim 7, wherein the breakable portion is made of a nonwoven fabric. ### Claim 9 (depends on 8) The medical member according to claim 8, wherein the breakable portion is constituted by a heated portion that has been subjected to heat treatment. ### Claim 10 A medical member comprising: a main body having a plurality of through-holes; and wherein the main body includes a breaking strength of the main body in a direction intersecting with a plane direction is represented by Y, a compression elongation percentage of the main body in the plane direction is represented by X, and a breakable portion having a relationship between the breaking strength and the compression elongation percentage, represented by the following formulas (1) to (4): Y ≤ 244734 ⁢ ( X - Z ) - 1.665 ( 1 ) 0 ≤ Z < 408.216 ( 2 ) X - Z > 0 ( 3 ) 39 ≤ X . ( 4 ) ### Claim 11 (depends on 10) The medical member according to claim 10, wherein 0≤Z≤351.466 is satisfied in the formula (2). ### Claim 12 (depends on 10) The medical member according to claim 10, wherein Z=0 is satisfied in the formula (2). ### Claim 13 (depends on 10) The medical member according to claim 10, wherein the breaking strength is 0.2 Newtons (N) to 16 N. ### Claim 14 (depends on 10) The medical member according to claim 10, wherein the compression elongation percentage is 39% to 1312%. ### Claim 15 (depends on 10) The medical member according to claim 10, wherein the breaking strength is 16 N or less, and the compression elongation percentage is 1414% or less. ### Claim 16 (depends on 10) The medical member according to claim 10, wherein at least a part of the breakable portion is disposed at a position closer to a center portion of the main body in the plane direction than an outer peripheral portion of the main body. ### Claim 17 (depends on 10) The medical member according to claim 10, wherein a constituent material of the breakable portion contains polyglycolic acid. ### Claim 18 (depends on 10) The medical member according to claim 10, wherein the breakable portion is made of a nonwoven fabric. ### Claim 19 A method for inducing expression of a biological component to anastomotic portions of a biological organ, the method comprising: disposing a medical member between a periphery of the anastomotic portions of the biological organ, the medical member including a main body having a plurality of through-holes, the main body includes, when a breaking strength of the main body in a direction intersecting with a plane direction is represented by Y, a compression elongation percentage of the main body in the plane direction is represented by X, and a breakable portion having a relationship between the breaking strength and the compression elongation percentage, represented by the following formulas (1) to (4): Y ≤ 244734 ⁢ ( X - Z ) - 1.665 ( 1 ) 0 ≤ Z < 408.216 ( 2 ) X - Z > 0 ( 3 ) 39 ≤ X ; ( 4 ) and passing a biological component of the biological organ through the through-holes of the main body of the medical device to induce expression of a biological component of the biological organ and promote adhesion by the induced biological component passing through the through-holes of the medical device. ### Claim 20 (depends on 19) The method according to claim 19, wherein biological organ is a large intestine, and the method further comprises: disposing the medical member between a periphery of a mouth portion of the large intestine and an intestinal wall of the large intestine; causing the periphery of the mouth portion of the large intestine and the intestinal wall of the large intestine to relatively approach each other; sandwiching the main body of the medical member between the periphery of the mouth portion of the large intestine and the intestinal wall of the large intestine; and performing joining in a state where the main body of the medical member is sandwiched between the periphery of the mouth portion of the large intestine and the intestinal wall of the large intestine.