Assessing a subject's adherene to a treatment for a condition

A screening system (100) for an undiagnosed medical condition, comprising:

• at least one controller (120, 190, 194) which is configured to:
• query a plurality of selected data sources (142, 144, 146, 148, 150, 152) for medical records to extract medical status information (MSI) of patients in a patient cohort;
• form patient cohort data (PCD) comprising patient case records, each of the patient case records comprising the extracted MSI of the patients in the patient cohort;
• exclude patient case records from the PCD that are determined to be disqualified according to exclusion rules (ERS), and update the PCD accordingly;
• determine risk factors that are present for each patient case record of the updated PCD in accordance with a comparison of the MSI for the corresponding patient case records with risk factors associated with the undiagnosed medical condition;
• determine a total risk score for each of the corresponding patient case records in accordance with a total of the determined risk factors that are determined to be present for the corresponding patient case records;
• determine a predicted probability of the undiagnosed medical condition based upon a logistic function of the determined total risk score for each of the corresponding patient case records;
• and
• assign each patient case record to a risk category or risk level in accordance with risk thresholds applied to the predicted probability of the undiagnosed medical condition.

A method for screening for a given undiagnosed medical condition in a patient cohort, the method comprising acts of:

• querying a plurality of selected data sources (142, 144, 146, 148, 150, 152) for medical records to extract medical status information (MSI) of patients in the patient cohort;
• forming patient cohort data (PCD) comprising patient case records, each of the patient case records comprising the extracted MSI of the patients in the patient cohort;
• excluding patient case records from the PCD that are determined to be disqualified according to exclusion rules (ERS), and updating the PCD accordingly;
• determining risk factors that are present for each patient case record of the updated PCD in accordance with a comparison of the MSI for the corresponding patient case records with risk factors associated with the undiagnosed medical condition;
• determine a total risk score for each of the corresponding patient case records in accordance with a total of the determined risk factors that are determined to be present for the corresponding patient case records;
• determining a predicted probability of the undiagnosed medical condition based upon a logistic function of the determined total risk score for each of the corresponding patient case records;
• and
• assigning each patient case record to a risk category or risk level in accordance with risk thresholds applied to the predicted probability of the undiagnosed medical condition.