Serum antibody profiling for leptospirosis
AssigneeSerimmune Inc.
InventorKathryn Vinaya Louise Kamath
Life of this patent
Estimating the term…
Abstract
Disclosed herein are reagents for use in antibody profiling platforms, such as biopanning and Digital Serology, specifically for eptiope motifs directed to Leptospira. Also disclosed herein are kits, method of manufacturing, and methods of using the same.
Claims59
A peptide display system, wherein the display system comprises:
- (a) one or more display surfaces;
- and
- (b) at least one distinct peptide, wherein the at least one distinct peptides comprises a binding motif, wherein the binding motif is selected from a motif group consisting of:
- [FM]TEX[FY]N (SEQ ID NO:4), KXGHDXC (SEQ ID NO:5), KGGXDX[IV] (SEQ ID NO:6), KXHG[IV]F (SEQ ID NO:7), HWFDXW (SEQ ID NO:8), HW[FL]DX[WF] (SEQ ID NO:9), ILQAD (SEQ ID NO:
- 10), LHADXXF (SEQ ID NO:11), [IVTP]LHAD (SEQ ID NO:
- 12), TLXAD[RSQ] (SEQ ID NO:13), KXIPAE (SEQ ID NO:14), [ED]XAGYN (SEQ ID NO:
- 15), [EDPA]X[AG][GA]YN (SEQ ID NO:
- 16), C[RL]XTDC (SEQ ID NO:17), [LIV]L[QH]AE (SEQ ID NO:
- 18), LPADR (SEQ ID NO:
- 19), [ML]XXLSAD (SEQ ID NO:20), [FWY]XP[RV]AD (SEQ ID NO:21), AD[QR]E[HQ] (SEQ ID NO:22), [FYL]XSAQP (SEQ ID NO:23), [SD]AQPX[WF] (SEQ ID NO:24), [TS]AQPXX[WR] (SEQ ID NO:25), MAGM[ED] (SEQ ID NO:26), CMAGM (SEQ ID NO:27), CMAGE (SEQ ID NO:28), GPAG[EQ] (SEQ ID NO:29), PAAG[TD] (SEQ ID NO:30), PAG[TD]XXX[WRSHTG] (SEQ ID NO:31), PA[GA][TD]XW (SEQ ID NO:32), [AP]AGT[MLI] (SEQ ID NO:33), CXDPQC (SEQ ID NO:34), [LF]EDKS (SEQ ID NO:35), and SXNLEQ (SEQ ID NO:36), and wherein the at least one distinct peptide extends from the one or more display surfaces.
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57-111. (canceled)
A peptide expression library, wherein the library comprises a library of nucleic acid sequences encoding a library of peptides, wherein the library of peptides comprises at least one distinct peptide, wherein the at least one distinct peptide comprises a binding motif, wherein the binding motif is selected from a motif group consisting of:
- [FM]TEX[FY]N (SEQ ID NO:4), KXGHDXC (SEQ ID NO:5), KGGXDX[IV] (SEQ ID NO:6), KXHG[IV]F (SEQ ID NO:7), HWFDXW (SEQ ID NO:8), HW[FL]DX[WF] (SEQ ID NO:9), ILQAD (SEQ ID NO:
- 10), LHADXXF (SEQ ID NO:11), [IVTP]LHAD (SEQ ID NO:12), TLXAD[RSQ] (SEQ ID NO:13), KXIPAE (SEQ ID NO:14), [ED]XAGYN (SEQ ID NO:
- 15), [EDPA]X[AG][GA]YN (SEQ ID NO:
- 16), C[RL]XTDC (SEQ ID NO:17), [LIV]L[QH]AE (SEQ ID NO:18), LPADR (SEQ ID NO:19), [ML]XXLSAD (SEQ ID NO:20), [FWY]XP[RV]AD (SEQ ID NO:21), AD[QR]E[HQ] (SEQ ID NO:22), [FYL]XSAQP (SEQ ID NO:23), [SD]AQPX[WF] (SEQ ID NO:24), [TS]AQPXX[WR] (SEQ ID NO:25), MAGM[ED] (SEQ ID NO:26), CMAGM (SEQ ID NO:27), CMAGE (SEQ ID NO:28), GPAG[EQ] (SEQ ID NO:29), PAAG[TD] (SEQ ID NO:30), PAG[TD]XXX[WRSHTG] (SEQ ID NO:31), PA[GA][TD]XW (SEQ ID NO:32), [AP]AGT[MLI] (SEQ ID NO:33), CXDPQC (SEQ ID NO:34), [LF]EDKS (SEQ ID NO:35), and SXNLEQ (SEQ ID NO:36).
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Dependencies are inferred from the claim text.