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US 2024/0191303 A1Published application
Methods for optimizing the treatment of colorectal cancer
AssigneeBrown University
InventorsWafik S. El-Deiry, Lindsey Carlsen
Life of this patent
Estimating the term…
Abstract
The invention provides a method for optimizing the treatment of colorectal cancer in a subject comprising the steps of extracting colorectal cancer cells from the subject, determining the transcriptional response in colorectal cancer cells across four or more clinically used chemotherapeutic drugs in terms of gene identity, magnitude of change, and p53 dependence, and determining the gene signature to determine the optimal course of treatment for the subject.
Claims7
A method for optimizing the treatment of gastrointestinal cancer in a subject comprising the steps of
- (a) obtaining gastrointestinal cancer cells extracted from the subject,
- (b) determining the transcriptional response in gastrointestinal cancer cells across four or more clinically used chemotherapeutic drugs in terms of gene identity, magnitude of change, and p53 dependence, and
- (c) determining the gene signature to determine the optimal course of treatment for the subject.
Dependencies are inferred from the claim text.