Biomarkers of aging for detection and treatment of disorders
AssigneesThe Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans Affairs
InventorsAnton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
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Abstract
Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
Claims23
A method of treating an adult mammal for an aging-associated impairment, the method comprising:
- modulating CCR3 in the mammal in a manner sufficient to treat the adult mammal for the aging-associated impairment.
The method according to any of the preceding claims, wherein the mammal is a primate.
The method according to any of the preceding claims, wherein the adult mammal is an elderly mammal.
The method according to any of the preceding claims, wherein the aging-associated impairment comprises a cognitive impairment.
The method according to any of the preceding claims, wherein the adult mammal suffers from an aging associated disease condition.
The method according to any of the preceding claims, wherein the aging associated disease condition is a cognitive decline disease condition.
Dependencies are inferred from the claim text.