Treatment of tumors with mirna targeting cdk4/cdk6
AssigneeInstitute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center
InventorsAmriti R. Lulla, Wafik S. El-Deiry
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Abstract
The present disclosure provides miRNA mimics targeting CDK4 and/or CDK6, and compositions comprising the same. Methods for the treatment of tumors, including but not limited to colon cancer, comprising administering a modified oligonucleotide comprising a miRNA are also disclosed herein.
Claims19
A method for treating a tumor or cancer comprising administering to a subject in need thereof one or more oligonucleotides consisting of 15 to 40 linked nucleobases, or a salt thereof, or a pharmaceutical agent that induces the production of the one or more oligonucleotides and/or induces PER1 expression, wherein the one or more oligonucleotides comprises a nucleobase sequence that is at least 80% identical to a nucleobase sequence of hsa-miR-6883-5p, hsa-miR-149-3p, hsa-miR-6785-5p, or hsa-miR-4728-5p.
Dependencies are inferred from the claim text.