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US 2024/0191230 A1Published application
Conjugates of sirna and antisense oligonucleotides (sirnaso) and methods of use in gene silencing
AssigneeUniversity of Massachusetts
InventorsJonathan Watts, Io Long Chan, Feng Wang, Minwook Shin
Life of this patent
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Abstract
This disclosure relates to compounds (“siRNASO”) comprising a double stranded RNA (dsRNA) attached to antisense oligonucleotides (ASO) and heteroduplex oligonucleotides (HDO). Also provided are methods of inhibiting gene expression with the same.
Claims37
A compound comprising:
- a) an siRNA comprising a sense strand and an antisense strand, and
- b) an antisense oligonucleotide (ASO),
- wherein the siRNA is attached to the ASO with a linker.
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A compound comprising:
- a) an siRNA comprising a sense strand and an antisense strand, and
- b) a heteroduplex oligonucleotide (HDO) comprising an antisense oligonucleotide (ASO) and a complementary oligonucleotide,
- wherein the siRNA is attached to the HDO with a linker.
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Dependencies are inferred from the claim text.