Application of amino acid-modified polymer for drug delivery
AssigneeProview-Mbd Biotech Co., Ltd.
InventorsYu-Chia CHANG, Yunn-Kuen CHANG, Wen-Yen HUANG, Ging-Ho HSIUE, Hsieh-Chih TSAI, Shuian-Yin LIN, Nai-Sheng HSU, Tzu-Yu LIN
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Abstract
Synthetic amino acid-modified polymers and methods of making the same and using the same are disclosed. The synthetic amino acid-modified polymers possess distinct thermosensitive, improved water-erosion resistant, and enhanced mechanical properties, and are suitable of reducing or preventing formation of postoperative tissue adhesions. Additionally, the amino acid-modified polymers can also be used as a vector to deliver pharmaceutically active agents.
Claims16
A method of drug delivery, comprising administering a pharmaceutically active agent and a polymer, wherein the polymer has powder, solution, or gel form, the pharmaceutically active agent and the polymer are applied by coating or spraying onto a wound site and the surfaces of surrounding tissues, and the polymer has a structure of the following formula (I):
- wherein:
- POLY is a triblock copolymer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide);
- m and n are independently from each other 0 or 1, wherein m and n cannot be 0 simultaneously;
- and
- AA is an amino acid residue, where its amino group directly binds to the chain-end of the POLY to form carbamate (O—C(═O)—NH) linkage.
A method of drug delivery, comprising administering a pharmaceutically active agent and a composition, wherein the composition has powder, solution, or gel form, the pharmaceutically active agent and the composition are applied by coating or spraying onto a wound site and the surfaces of surrounding tissues, and the composition comprises any one of polymer having a structure of the following formula (I):
- or a combination thereof, and a pharmaceutically acceptable carrier;
- wherein:
- POLY is a triblock copolymer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide);
- m and n are independently from each other 0 or 1, wherein m and n cannot be 0 simultaneously;
- and
- AA is an amino acid residue, where its amino group directly binds to the chain-end of the POLY to form carbamate (O—C(═O)—NH) linkage.
Dependencies are inferred from the claim text.