Functionalized diblock copolymer and its preparation method and application
AssigneeInnovatingBio (Shanghai) Co.,Ltd.
InventorsChun ZHOU, Zhenxing YE, Chenhong LU
Life of this patent
Estimating the term…
Abstract
A functionalized diblock copolymer having the chemical structure shown in Formula I. The functionalized diblock copolymer or polymer particles can be widely used in tumor imaging, tumor therapy and other fields. It not only has good safety, realizes faster and adjustable degradation and removal of polymers (by changing the structure and number of functional groups) under acidic conditions, but also has excellent specific and high-quality imaging effects at the target site, with high signal-to-noise ratio, clear boundaries, long half-life, etc., which solves the problem of fluorescence imaging technology in real-time intraoperative navigation, and thus has a good industrialization prospect.
Claims12
A functionalized diblock copolymer, wherein the chemical structure of the functionalized diblock copolymer is shown in Formula I:
- wherein in Formula I, m1=22˜1136, n1=10˜500, o1=0˜50, p1=0.5˜50, q1=0˜500 and r1=0˜200;
- s11=1˜10, s12=1˜10, s13=1˜10, s14=1˜10;
- t11=1˜10, t12=1˜10, t13=1˜10, t14=1˜10;
- L11, L12, L13 and L14 are linking groups;
- A1 is selected from protonatable groups;
- B1 is selected from degradability-regulating groups;
- C1 is selected from fluorescent molecular groups;
- D1 is selected from delivery molecular groups;
- E1 is selected from hydrophilic or hydrophobic groups;
- T1 is selected from capping groups;
- and
- EG1 is selected from capping groups.
Dependencies are inferred from the claim text.