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US 2024/0190995 A1Published application
Separation media and purification methods for blood antibodies using the same
AssigneeDonaldson Company, Inc.
InventorsJinxiang Zhou, Graham Temples
Life of this patent
Estimating the term…
Abstract
Separation media that includes a support substrate and a plurality of separation ligands immobilized on the support substrate. The plurality of separation ligands include an affinity capable of recognizing and binding to blood type antigen recognizing domain. Methos of making the separation media and methods of using the separation media.
Claims21
1-33. (canceled)
A separation media comprising:
- a support substrate;
- and
- a plurality of separation ligands for formula SL1 or SL2
- wherein:
- Z is a separation group comprising an affinity group, the affinity group comprising a blood type antigen or a fragment thereof;
- and
- Rp1, Rp3, and Rp4 each independently comprise the reaction product of any one of RpA, RpB, RpC, RpD, RpE, RpF, RpG, RpH, RpI, RpJ, RpK, or an isomer thereof, wherein rpA, RpB, RpC, RpD, RpE, RpF, RpG, RpH, RpI, RpJ, and RpK are represented by:
- wherein:
- U0, U1, U2, U3, U4, U5, U6, and U7 are each independently NH, O, or S;
- and
- Sp is a spacer comprising a divalent organic group, and
- wherein the separation media configured for isolating a target molecule comprising a blood type antigen recognizing domain.
9 more elements
The separation media of claim 1, wherein Sp comprises —C(O)—.
Dependencies are inferred from the claim text.