Bispecific antibody that binds to cd116 and cd131
AssigneeKyowa Kirin Co., Ltd.
InventorsAkifumi KATO, Harue NISHIYA, Ryosuke NAKANO, Toshimasa HARUMOTO
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Abstract
An object of the present invention is to provide a bispecific antibody having an agonist activity to a GM-CSF receptor, and a bispecific antibody fragment thereof. The present invention relates to a bispecific antibody or a bispecific antibody fragment thereof containing: a first antigen-binding domain; and a second antigen-binding domain, in which one of the first antigen-binding domain and the second antigen-binding domain is an antigen-binding domain binding to CD116, and the other one is an antigen-binding domain binding to CD131.
Claims16
A bispecific antibody or a bispecific antibody fragment thereof comprising:
- a first antigen-binding domain;
- and
- a second antigen-binding domain, wherein
- the first antigen-binding domain is an antigen-binding domain binding to CD131, and the second antigen-binding domain is an antigen-binding domain binding to CD116, and
- the first antigen-binding domain comprises a VH comprising CDRs 1 to 3 comprising the amino acid sequences represented by SEQ ID NOs:
- 85 to 87, respectively, and a VL comprising CDRs 1 to 3 comprising the amino acid sequences represented by SEQ ID NOs:
- 88 to 90, respectively, and the second antigen-binding domain comprises a VH comprising CDRs 1 to 3 comprising the amino acid sequences represented by SEQ ID NOs:
- 137 to 139, respectively, and a VL comprising CDRs 1 to 3 comprising the amino acid sequences represented by SEQ ID NOs:
- 88 to 90, respectively.
Dependencies are inferred from the claim text.