Anti-human interleukin-4 receptor alpha antibody and preparation method and application thereof
AssigneeShanghai Mabgeek Biotech. Co., Ltd.
InventorsChenghai Zhang, Jinlin Guo, Yujing Yuan
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Abstract
The present invention discloses an antibody capable of binding to human interleukin 4 receptor alpha (hIL-4R alpha) and a preparation method and application thereof. The anti-hIL-4R alpha antibody can specifically bind to hIL-4R alpha, has good effects for inhibiting IL-4 and IL-13-induced cell line proliferation and the like, and can be applied to treatment of IL-4R alpha related diseases, such as immune-mediated inflammatory diseases.
Claims18
1-17. (canceled)
An antibody specifically binding to interleukin-4 receptor alpha or an antigen-binding fragment thereof, comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises an HCDR1 sequence, an HCDR2 sequence and an HCDR3 sequence, the light chain variable region comprises an LCDR1, an LCDR2 and an LCDR3 sequence, wherein,
- (a) the HCDR1 sequence comprises the amino acid sequence of SEQ ID NO:
- 129;
- the HCDR2 sequence comprises the amino acid sequence of SEQ ID NO:
- 130;
- the HCDR3 sequence comprises the amino acid sequence of SEQ ID NO:
- 131;
- the LCDR1 sequence comprises the amino acid sequence of SEQ ID NO:
- 132;
- the LCDR2 sequence comprises the amino acid sequence of SEQ ID NO:
- 133;
- and
- the LCDR3 sequence comprises the amino acid sequence of SEQ ID NO:
- 134 with an L8F mutation,
- (b) the HCDR1 sequence comprises the amino acid sequence of SEQ ID NO:
- 123;
- the HCDR2 sequence comprises the amino acid sequence of SEQ ID NO:
- 124;
- the HCDR3 sequence comprises the amino acid sequence of SEQ ID NO:
- 125;
- the LCDR1 sequence comprises the amino acid sequence of SEQ ID NO:
- 126;
- the LCDR2 sequence comprises the amino acid sequence of SEQ ID NO:
- 127;
- and
- the LCDR3 sequence comprises the amino acid sequence of SEQ ID NO:
- 128;
- or
- (c) the HCDR1 sequence comprises the amino acid sequence of SEQ ID NO:
- 201;
- the HCDR2 sequence comprises the amino acid sequence of SEQ ID NO:
- 202;
- the HCDR3 sequence comprises the amino acid sequence of SEQ ID NO:
- 203;
- the LCDR1 sequence comprises the amino acid sequence of SEQ ID NO:
- 204;
- the LCDR2 sequence comprises the amino acid sequence of SEQ ID NO:
- 205;
- and
- the LCDR3 sequence comprises the amino acid sequences of SEQ ID NO:
- 206.
Dependencies are inferred from the claim text.