Anti-ly6g6d antibodies and methods of use

An isolated antibody that binds to lymphocyte antigen 6 family member G6D (LY6G6D), wherein the antibody comprises a LY6G6D binding domain comprising a heavy chain polypeptide (H1) and a light chain polypeptide (L1), wherein the H1 comprises a heavy chain variable (VH) domain (VH1) comprising the following complementarity determining regions (CDRs):

• (a) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
• 4;
• (b) a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
• 5;
• and
• (c) a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
• 6;
• and
• the L1 comprises a light chain variable (VL) domain (VL1) comprising the following CDRs:
• (d) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
• 1;
• (e) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
• 2;
• and
• (f) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
• 3.

An isolated antibody that binds to LY6G6D, wherein the antibody comprises a LY6G6D binding domain comprising a heavy chain polypeptide (H1) and a light chain polypeptide (L1), wherein:

• (a) the H1 comprises a VH domain (VH1) comprising the amino acid sequence of SEQ ID NO:
• 10 and the L1 comprises a VL domain (VL1) comprising the amino acid sequence of SEQ ID NO:
• 11;
• or
• (b) the H1 comprises a VH domain (VH1) comprising the amino acid sequence of SEQ ID NO:
• 59 and the L1 comprises a VL domain (VL1) comprising the amino acid sequence of SEQ ID NO:
• 60.