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US 2024/0190962 A1Published application
Immunocytokines and uses thereof
AssigneeImmunowake Inc.
InventorsEllen WU, Xiaoyun WU, John WAKEFIELD
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Abstract
The present application relates to immunocytokines comprising a cytokine or variant thereof positioned at the hinge region of a heavy chain of an antibody (e.g., full-length antibody), or positioned at a hinge region between an antigen-binding fragment (e.g., ligand, receptor, or antibody fragment) and an Fc domain subunit or portion thereof, methods of making, and uses thereof.
Claims40
An immunocytokine comprising:
- a) an antigen-binding protein specifically recognizing a target antigen;
- and b) a cytokine or variant thereof, wherein the antigen-binding protein comprises an antigen-binding polypeptide comprising from N′ to C′:
- an antigen-binding fragment, a hinge region, and an Fc domain subunit or portion thereof, and wherein the cytokine or variant thereof is positioned at the hinge region;
- and wherein the target antigen is PD-1:
- and the antigen-binding protein specifically binds the target antigen with a KD within a range of 10−8M<KD≤10−6M.
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Dependencies are inferred from the claim text.