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US 2024/0190959 A1Published application
Antigen Binding Proteins that Bind PD-L1
AssigneeYuhan Corporation
InventorHeyue Zhou
Life of this patent
Estimating the term…
Abstract
There is disclosed anti-PD-L1 IgG class antibodies that have an improved ability to be manufactured at higher yields. More specifically, there is disclosed human antibodies that bind PD-L1, PD-L1-binding fragments that can be manufactured at higher yields.
Claims14
1-18. (canceled)
A host cell comprising (1) a vector comprising a nucleic acid that encodes a PD-L1-binding polypeptide wherein the polypeptide comprises a heavy chain variable domain comprising a CDR1 domain, a CDR2 domain, and a CDR3 domain as set forth in the amino acid sequences of SEQ ID NO:
- 5, SEQ ID NO:
- 6, and SEQ ID NO:
- 7, respectively, and comprises a light chain variable domain comprising an amino acid sequence as set forth in SEQ ID NO. 2 or SEQ ID NO. 3;
- or (2) a first vector comprising a nucleic acid that encodes a heavy chain variable domain comprising a CDR1 domain, a CDR2 domain, and a CDR3 domain as set forth in the amino acid sequences of SEQ ID NO:
- 5, SEQ ID NO:
- 6, and SEQ ID NO:
- 7, respectively and a second vector comprising a light chain variable domain comprising an amino acid sequence as set forth in SEQ ID NO. 2 or SEQ ID NO. 3.
4 more elements
Dependencies are inferred from the claim text.