Il-11 antibodies
AssigneesSingapore Health Services Pte Ltd, National University of Singapore, Boehringer Ingelheim International GmbH
InventorsStuart Alexander Cook, Sebastian Schaefer
Life of this patent
Estimating the term…
Abstract
Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.
Claims17
1-25. (canceled)
An antigen-binding molecule which binds specifically to IL-11, wherein the antigen-binding molecule comprises:
- a VH region comprising an amino acid sequence having at least 99% sequence identity to the amino acid sequence of SEQ ID NO:117;
- and
- a VL region comprising an amino acid sequence having at least 99% sequence identity to the amino acid sequence of SEQ ID NO:
- 122.
A nucleic acid, or a plurality of nucleic acids, encoding an antigen-binding molecule which binds specifically to IL-11, wherein the antigen-binding molecule comprises:
- a VH region comprising an amino acid sequence having at least 99% sequence identity to the amino acid sequence of SEQ ID NO:117;
- and
- a VL region comprising an amino acid sequence having at least 99% sequence identity to the amino acid sequence of SEQ ID NO:122.
A method of treating or preventing a disease or condition in a subject, the method comprising administering to a subject in need thereof a therapeutically or prophylactically effective amount of an antigen-binding molecule that specifically binds to IL-11, wherein the antigen-binding molecule comprises:
- a VH region comprising an amino acid sequence having at least 99% sequence identity to the amino acid sequence of SEQ ID NO:117;
- and
- a VL region comprising an amino acid sequence having at least 99% sequence identity to the amino acid sequence of SEQ ID NO:122,
- wherein the disease or condition is selected from the group consisting of:
- fibrosis, a disease characterised by fibrosis, a cancer, inflammation, a disease characterised by inflammation, hepatotoxicity, a disease characterised by hepatotoxicity, a metabolic disease, a wasting disorder, kidney injury, nephrotoxicity, and a disease characterised by hepatotoxicity.
Dependencies are inferred from the claim text.