IL-18 Binding Protein (IL-18BP) and Antibodies for Treating Inflammatory Diseases
AssigneeAB2 Bio SA
InventorsGreg Del Val, Eduardo Schiffrin
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Abstract
The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders. In particular, the present invention discloses antibodies specific for free IL-18 and IL-18 Binding Protein (IL-18BP) for use in such treatments and for the diagnosis of the diseases and disorders.
Claims21
1-25. (canceled)
A method for the treatment of an IL-18 associated autoinflammatory disease or disorder and/or symptoms associated with said disease or disorder in a subject, said method comprising administering to said subject an IL-18 inhibitor, wherein the IL-18 inhibitor is an IL-18 binding protein (IL-18BP) or an active fragment thereof, wherein the IL-18BP or the active fragment thereof comprises N-terminal and/or C-terminal deletion variants of IL-18BP, which are present in an amount of less than 30%.
Dependencies are inferred from the claim text.