Compositions and methods comprising sfrp2 antagonists
AssigneeThe University of North Carolina at Chapel Hill
InventorsNancy Demore, Cam Patterson
Life of this patent
Estimating the term…
Abstract
The present disclosure provides humanized antibodies and antigen-binding fragments thereof that specifically bind to SFRP2 and compositions comprising such humanized antibodies or antigen-binding fragments thereof. In some aspects, the humanized antibodies or antigen-binding fragments can be used to treat diseases or conditions associated with increased SFRP2, such as cancer. In some aspects, the antibodies or antigen-binding fragments can be used to treat osteosarcoma.
Claims6
1-21. (canceled)
A method of treating cancer in a patient, the method comprising administering to the patient a pharmaceutical composition of comprising a therapeutically effective amount of a humanized anti-secreted frizzled-related protein 2 (SFRP2) antibody or antigen binding fragment thereof which binds SFRP2, wherein said humanized antibody or antigen binding fragment thereof comprises a variable heavy (VH) chain polypeptide and a variable light (VL) chain polypeptide comprising the amino acid sequences of SEQ ID NO:
- 2 and SEQ ID NO:
- 9, respectively, and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.