Human insulin c-alpha-peptides and methods of use
AssigneeThe United States of America, as represented by the Secretary, Dept. of Health and Human Services
InventorsQing-Rong Liu, Min Zhu, Pingbo Zhang, Josephine M. Egan
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Abstract
Methods of treating a subject with diabetes or Alzheimer's disease with a disclosed insulin isoform or Cα polypeptide are provided. Methods of detecting insulin isoforms or Cα polypeptides are also provided.
Claims28
A method of treating a subject with diabetes or Alzheimer's disease or inhibiting amyloidosis in a subject, comprising administering to the subject a composition comprising an insulin Cα peptide to a subject in need thereof.
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A set of one or more peptides selected from the group consisting of the amino acid sequences of SEQ ID NOs:
- 54-64.
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A modified insulin Cα peptide comprising or consisting of the amino acid sequence of SEQ ID NO:
- 7 or SEQ ID NO:
- 8 and one or more peptide modifications.
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Dependencies are inferred from the claim text.