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US 2024/0190934 A1Published application
Engineered interleukin-10 and fusion proteins thereof
OwnerHung-Kai Chen, Po-Hao Chang +2inventors
InventorsHung-Kai Chen, Po-Hao Chang, Wei Huang, Jing-Yi Huang
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Abstract
The present disclosure provides an IL-10 variant protein, a fusion protein comprising the IL-10 variant protein and a polypeptide, and the use thereof. The present disclosure also provides a method of producing the same and a pharmaceutical composition comprising the same.
Claims18
An IL-10 variant protein, comprising:
- (1) a single substitution of amino acid at position 18, relative to amino acids of wild-type IL-10;
- (2) a first substitution of amino acid at position 18 and a second substitution of amino acid at position 104 or position 107, relative to amino acids of wild-type IL-10;
- or (3) a first substitution of amino acid at position 18, a second substitution of amino acid at position 104 and a third substitution of amino acid at position 107, relative to amino acids of wild-type IL-10.
Dependencies are inferred from the claim text.