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AssigneeCue Biopharma, Inc.
InventorsRonald D. SEIDEL, III, John F. ROSS, Chee Meng LOW
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The present disclosure provides Multimeric Antigen Presenting Polypeptides (MAPPs) that comprise a TID-associated peptide epitope and a reversibly masked TGF-β peptide capable of acting as an agonist of cellular TGF-β receptors. The MAPPs are capable of presenting the TID-associated peptide epitope in the context of a Class II MHC receptor to T cells. The present disclosure provides nucleic acids comprising nucleotide sequences encoding those MAPPs, as well as cells genetically modified with the nucleic acids encoding those MAPPs. MAPPs of the present disclosure are useful for selectively modulating activity of a T cells having T cell receptors that recognize the TID epitopes presented by the MAPP. Thus, the present disclosure provides compositions and methods for modulating the activity of T cells, as well as compositions and methods for treating persons who have TID.
A multimeric antigen-presenting polypeptide (MAPP) comprising:
Dependencies are inferred from the claim text.