Magec2 immunogenic peptides, binding proteins recognizing magec2 immunogenic peptides, and uses thereof
AssigneesTScan Therapeutics, Inc., Academisch Ziekenhuis Leiden
InventorsAndrew P. Ferretti, Yifan Wang, Gavin MacBeath, Qikai Xu
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Abstract
Provided herein are MAGEC2 immunogenic peptides, binding proteins recognizing MAGEC2 immunogenic peptides, and uses thereof.
Claims142
An immunogenic peptide comprising a peptide epitope selected from peptide sequences listed in Table 1.
An immunogenic peptide consisting of a peptide epitope selected from peptide sequences listed in Table 1.
A composition comprising a peptide epitope selected from peptide sequences listed in Table 1, and an MHC molecule.
A method of identifying a peptide-binding molecule, or antigen-binding fragment thereof, that binds to a peptide epitope selected from the peptide sequences listed in Table 1 comprising:
- a) providing a cell presenting a peptide epitope selected from the peptide sequences listed in Table 1 in the context of an MHC molecule on the surface of the cell;
- b) determining binding of a plurality of candidate peptide-binding molecules or antigen-binding fragments thereof to the peptide epitope in the context of the MHC molecule on the cell;
- and
- c) identifying one or more peptide-binding molecules or antigen-binding fragments thereof that bind to the peptide epitope in the context of the MHC molecule.
A TCR alpha chain and/or beta chain selected from the group consisting of TCR alpha chain and beta chain sequences listed in Table 2.
An isolated nucleic acid molecule i) that hybridizes, under stringent conditions, with the complement of a nucleic acid encoding a polypeptide selected from the group consisting of polypeptide sequences listed in Table 2, ii) a sequence with at least about 80% homology to a nucleic acid encoding a polypeptide selected from the group consisting of the polypeptide sequences listed in Table 2, and/or iii) ii) a sequence with at least about 80% homology to a nucleic acid encoding listed in Table 2, optionally wherein the isolated nucleic acid molecule comprises 1) a TRAV, TRAJ, and/or TRAC gene or fragment thereof selected from the group of TRAV, TRAJ, and TRAC genes listed in Table 2 and/or 2) a TRBV, TRBJ, and/or TRBC gene or fragment thereof selected from the group of TRBV, TRBJ, and TRBC genes listed in Table 2.
Dependencies are inferred from the claim text.