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US 2024/0190910 A1Published application
Hemi-citrate salts of gaba-a positive allosteric modulator and crystalline form thereof
AssigneePraxis Precision Medicines, Inc.
InventorsDoris NEVILLE, Ahmad HASHASH, Karl HANSEN, Johann CHAN
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Abstract
Disclosed herein are hemi-citrate salts of Compound (1), crystalline forms thereof, methods of their preparation, pharmaceutical compositions thereof, and methods of their use.
Claims45
A substantially pure hemi-citrate salt of Compound 1 having the formula:
A method of preparing a hemi-citrate salt of Compound 1 having the formula:
- the method comprising:
- (a) dissolving a mono-citrate salt of Compound 1 in C1-C2 alcohol to produce a solution;
- and
- (b) adding the solution to water to provide the hemi-citrate salt of Compound 1.
1 more element
A method of preparing a hemi-citrate salt of Compound 1 having the formula:
- the method comprising:
- (a) suspending a mono-citrate salt of Compound 1 in water;
- and
- (b) isolating the hemi-citrate salt of Compound 1.
1 more element
Dependencies are inferred from the claim text.