Compounds for programmable protein degradation and methods of use for the treatment of disease

Abstract

Compounds of Formula (IA) (Targeting Moiety)-(Linker)-(Protease Ligand)  (IA), where the targeting moiety is an oligonucleotide capable of binding a target protein and the protease ligand is a ligand capable of binding a protease, and methods for the use thereof are provided. Also provided are compounds of Formula (IB) (Targeting Moiety)-(Linker)-(Protease Ligand or E3 Ligase Ligand)  (IB), where the targeting moiety is an oligonucleotide capable of binding a target protein, the protease ligand is a ligand capable of binding a protease, and the E3 ligase ligand is a ligand capable of binding an E3 ligase, and methods for the use thereof are provided.

Dependencies are inferred from the claim text.