New cyclopenta-thieno-diazepine derivatives as gaba a gamma1 positive allosteric modulators

A compound of formula (I)

• or a pharmaceutically acceptable salt thereof, wherein:
• is selected from:
• R1 is selected from hydrogen, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, hydroxy-C1-C6-alkyl, C3-C10-cycloalkyl, amino-C1-6-alkyl, 5-14-membered heteroaryl, 3-14-membered heterocycloalkyl, (3-14-membered heterocycloalkyl)-C(O)—, and —C(O)NR5R6;
• wherein said C3-C10-cycloalkyl, 5-14-membered heteroaryl and 3-14-membered heterocycloalkyl are optionally substituted by 1-3 substituents that are each independently selected from halogen, cyano, hydroxy, oxo, amino, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, and halo-C1-C6-alkoxy;
• R2 is selected from hydrogen, C1-C6-alkyl, and C1-C6-alkoxy;
• R3 is selected from chloro and fluoro;
• R4 is selected from C1-C6-alkyl, halo-C1-C2-alkyl, and cyano;
• and
• R5 and Re are each independently selected from hydrogen, C1-C6-alkyl, and hydroxy-C1-C6-alkyl.