Spiro-containing derivative, and preparation method therefor and use thereof

A compound represented by general formula (I), a stereoisomer or a pharmaceutically acceptable salt thereof,

• wherein
• M1 and M2 are each independently selected from —(CRARB)n—, O or S;
• M3 is selected from CRa, N or S;
• M4 is selected from CRb, N or S;
• M5 is selected from CRc, N or S;
• RA, RB, Ra, Rb and Rc are each independently selected from hydrogen, deuterium, halogen, hydroxyl, cyano, amino, C1-6 alkyl, C1-6 deuterated alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 alkylamine;
• R1 and R2 together with the carbon atom to which they are connected are linked to form a C3-8 cycloalkyl or a 3-8 membered heterocyclyl;
• R3 and R4 are each independently selected from hydrogen, deuterium, halogen, hydroxyl, cyano, C1-6 alkyl, C1-6 deuterated alkyl or C1-6 haloalkyl;
• alternatively, R3 and R4 together with the nitrogen atom to which they are connected are linked to form a 3-8 membered nitrogen-containing heterocyclyl;
• R5 and R6 are each independently selected from hydrogen, deuterium, halogen, hydroxyl, cyano, C1-6 alkyl, C1-6 deuterated alkyl or C1-6 haloalkyl;
• alternatively, R5 and R6 together with the carbon atom to which they are connected are linked to form a C3-8 cycloalkyl or a 3-8 membered heterocyclyl;
• alternatively, R5 or R6 is linked with R3 or R4 to form a 3-8 membered nitrogen-containing heterocyclyl;
• R7 is selected from hydrogen, deuterium, halogen, hydroxyl, cyano, C1-6 alkyl, C1-6 deuterated alkyl or C1-6 haloalkyl;
• alternatively, R7 is linked with R3 or R4 to form a 4-8 membered nitrogen-containing heterocyclyl;
• alternatively, R7 is linked with R5 or R6 to form a C3-8 cycloalkyl or a 3-8 membered heterocyclyl;
• the cycloalkyl or heterocyclyl formed by linking R1 and R2 together with the carbon atom to which they are connected, the nitrogen-containing heterocyclyl formed by linking R3 and R4 together with the nitrogen atom to which they are connected, the cycloalkyl or heterocyclyl formed by linking R5 and R6 together with the carbon atom to which they are connected, the nitrogen-containing heterocyclyl formed by lining R5 or R6 with R3 or R4, the nitrogen-containing heterocyclyl formed by linking R7 with R3 or R4, or the cycloalkyl or heterocyclyl formed by linking R7 with R5 or R6, optionally further substituted by one or more substituents selected from the group consisting of hydrogen, deuterium, halogen, hydroxyl, cyano, nitro, amino, C1-6 alkyl, C1-6 alkoxy, —(CH2)n1ORaa, —(CH2)n1SRaa, —(CH2)n1NRaaRbb, —(CH2)n1NRaaC(O)Rbb, —(CH2)n1C(O)NRaaRbb, —(CH2)n1C(O)Raa, —(CH2)n1C(O)ORaa, —(CH2)n1S(O)2Raa, —(CH2)n1NRaaS(O)2Rbb and —(CH2)n1S(O)2NRaaRbb;
• Raa and Rbb are each independently selected from hydrogen, deuterium, halogen, hydroxyl, cyan, nitro, amino, C1-6 alkyl, C1-6 deuterated alkyl or C1-6 haloalkyl;
• n is an integer from 0 to 2;
• and
• n1 is an integer from 0 to 2.