Compound used as shp2 inhibitor and use thereof

A compound of formula I′, or a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof,

• wherein,
• R1 is selected from the group consisting of bicyclic C6-C10 aryl, 6-10 membered heteroaryl containing 1-3 heteroatoms selected from N, O, and S, C6-C10 aryl heterocycloalkyl;
• any hydrogen atom on R1 is optionally substituted by one or more of the following substituents:
• deuterium, hydroxyl, halogen, cyano, ═O, ester, acylamino, ketocarbonyl, amino, hydroxyl-substituted C1-C4 alkyl, —C(O)ORa, —NHC(O)Ra, —NHC(O)ORa, —C(O)(C1-C4 alkylene)OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 thioalkyl, C1-C6 alkoxy, C1-C6 heteroalkyl, C1-C6 alkylamino, C3-C6 cycloalkyl, C3-C8 cycloalkylamino, C6-C10 aryl, and 6-10 membered heteroaryl containing 1-3 heteroatoms selected from N, O and S;
• Ra is C1-C4 alkyl;
• the C6-C10 aryl heterocycloalkyl is —(C6-C10 aryl) fused (saturated or unsaturated 3-8 membered heterocycloalkyl containing 1-3 heteroatoms selected from N, O and S);
• R1 is a bicyclic and fused-ring structure;
• R2 is selected from the group consisting of H, deuterium, amino, cyano, halogen, hydroxyl, methyl, CH2OH, CH(CH3)OH, C(CH3)2OH, halomethyl, deuterated methyl, CONH2, CF2OH, NHSO2Me, and CH2NHSO2Me;
• R3 is selected from the group consisting of hydrogen, deuterium, hydroxyl, amino, cyano, halogen, methyl, deuteromethyl, and halomethyl;
• ring A is selected from the group consisting of:
• monocyclic or bicyclic 3-11 membered heterocycloalkyl containing 1-3 heteroatoms selected from N, O and S, 6-10 membered heteroaryl containing 1-3 heteroatoms selected from N, O and S, -(3-8 membered heterocycloalkylene containing 1-3 heteroatoms selected from N, O and S)-(3-8 membered heterocycloalkyl containing 1-3 heteroatoms selected from N, O and S), 4-8 membered bridged heterocycloalkyl containing 1-3 heteroatoms selected from N, O and S;
• any hydrogen atom on ring A is unsubstituted or monosubstituted, disubstituted or trisubstituted by the following substituents:
• (CH2),NHR′1, (CH2),CONH2, (CH2)nCF2H, (CH2)nCF3, (CH2)nOH, ═O, C1-C6 alkyl, halogen, amino, hydroxyl, —N—(C1-C6 alkyl), —(C1-C6 alkylene)—NH2, wherein the hydrogen on the alkyl is unsubstituted or monosubstituted or disubstituted by OR′1;
• R′1 is selected from the group consisting of:
• H, C1-C4 alkyl, and hydroxyl-substituted C1-C4 alkyl;
• and
• n is selected from the group consisting of 0, 1, 2 and 3.