Back to results
US 2024/0190877 A1Published application
Pharmacophore for trail induction
AssigneeThe Scripps Research Institute
InventorsKim D. JANDA, Nicholas T. JACOB, Jonathan W. LOCKNER
Life of this patent
Estimating the term…
Abstract
There are disclosed imidazolinopyrimidinone compounds that have activity to induce TRAIL gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of Formula I herein.
Claims9
A compound of formula (I)
- wherein
- Cyc is a 5- to 8-membered monocyclic heterocyclyl ring comprising one nitrogen atom, with a group of formula Ar1-CR2-being bonded to the ring nitrogen atom;
- Ar1 and Ar2 are each independently aryl groups which are substituted with 0, 1, or 2 J groups;
- R is independently H or (C1-C6)alkyl;
- J is independently (C1-C6)alkyl, (C3-C9)cycloalkyl, (C3-C9)cycloalkyl(C1-C6)alkyl, halo, or (C1-C6)haloalkyl;
- or a pharmaceutically acceptable salt thereof.
3 more elements
A method for treating cancer, comprising administering an effective amount of a compound of formula (I)
- wherein
- Cyc is a 5- to 8-membered monocyclic heterocyclyl ring comprising one nitrogen atom, with a group of formula Ar1—CR2-being bonded to the nitrogen atom;
- Ar1 and Ar2 are aryl groups which are substituted with 0, 1, or 2 J groups;
- R is independently H or (C1-C6)alkyl;
- J is independently (C1-C6)alkyl, (C3-C9)cycloalkyl, (C3-C9)cycloalkyl(C1-C6)alkyl, halo, or (C1-C6)haloalkyl;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.