Sos1 inhibitors

A compound of formula I:

• or a pharmaceutical acceptable salt, solvate, isomer, prodrug, or tautomer thereof, wherein:
• A is C3-C6 cycloalkyl, 4-10 membered heterocycloalkyl, aryl, or 5-10 membered heteroaryl;
• L is a single bond, —O—, —C(O)—, —C(O)O—, —O—CO—, —C(O)NR′—, —NR′—, —NR′CO—, —NR′SO2—, —SO2NR′—, —S—, —SO—, —S(O)2—, C1-C3 alkylene, C1-C3 haloalkylene, C2-C3 alkenylene, or C2-C3 alkynylene, in which R′ is H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, 3-6 membered heterocycloalkyl, 5-10 membered heteroaryl, or 6-10 membered aryl;
• M is a C5-C10 cycloalkyl, 5-15 membered heterocyclyl, 6-10 membered aryl, or 5-10 membered heteroaryl;
• Q indicates the left ring of Formula I to which M is fused;
• R1 is CN, C1-C3 alkyl, C2-C3 alkenyl, or C2-C3 alkynyl;
• R2 is H, CN, halogen, C1-C3 alkyl, C1-C3 alkoxy, C2-C3 alkynyl, or C3-C6 cycloalkyl;
• R3 is C1-C6 alkyl, C3-C6 cycloalkyl, 4-6 membered heterocycloalkyl, 5-6 membered heteroaryl, or phenyl;
• or R2 and R3, together with the carbon atom to which R2 bonds and the nitrogen atom to which R3 bonds, form a 4-7 membered heterocycloalkyl;
• R4 is H, C1-C10 alkyl, C1-C10 alkylamino, C1-C10 alkylamido, C2-C10 alkylcarbonyl, C1-C10 alkylsulfonyl, C1-C10 alkysulfonamido, C3-C6 cycloalkyl, C3-C6 cycloalkylcarbonyl, C3-C6 cycloalkylamido, 3-10 membered heterocycloalkyl, 6-10 membered aryl, or 5-10 membered heteroaryl;
• is a single or double bond;
• and
• each of alkyl, alkylene, alkenyl, alkynyl, alkoxy, haloalkylene, alkylamino, alkylamido, alkylcarbonyl, alkylsulfonyl, alkysulfonamido, alkynylene, cycloalkyl, cycloalkylcarbonyl, cycloalkylamido, heterocycloalkyl, heterocyclyl, phenyl, aryl, and heteroaryl is unsubstituted or substituted with one or more groups selected from deuterium, halogen, CN, oxo, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, —OR′, —C(O)R′, —C(O)OR′, —O—COR′, —C(O)NR′R″, —NR′R″, —SR′, —SOR′, —S(O)2R′, and —POR′R″, in which each of R′ and R″, independently, is H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, 3-6 membered heterocycloalkyl, 5-10 membered heteroaryl, or 6-10 membered aryl.