T-type calcium channel antagonists and uses thereof

A compound of Formula (II):

• or a pharmaceutically acceptable salt thereof, wherein
• ring B is C6-C10 aryl or 5- to 10-membered heteroaryl;
• R1, R2, and R3 are each independently H, halogen, CN, OR11, NR12aR12b, C1-C6 alkyl, C2-C6 alkoxyalkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, phenyl, 5- to 6-membered heteroaryl, C3-C7 cycloalkyl, —(CH2)n—(C3-C7 cycloalkyl), 4- to 7-membered heterocyclyl, or —(CH2)n-(4- to 7-membered heterocyclyl), wherein the phenyl, heteroaryl, cycloalkyl or heterocyclyl is optionally substituted by 1, 2, or 3 halogen, CN, OR11, NR12aR12b, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylamino, or C1-C6 haloalkyl;
• R4a and R4b are each independently H or C1-C6 alkyl, or R4a and R4b and the carbon atom to which they are attached form a C3-C5 cycloalkyl;
• R6 is H, C1-C6 alkyl, or C1-C6 haloalkyl;
• X1 and X5 are each independently N or CR8, provided that at least one of X1 and X5 is CR8;
• X2, X3, and X4 are each independently N, NR9, O, S, or CR9, provided that at least one of X2, X3, and X4 is N, NR9, O, or S;
• R8 is H, halogen, CN, OR11, C1-C6 alkyl, C2-C6 alkoxyalkyl, or C1-C6 haloalkyl;
• R9 is H, C1-C6 alkyl, C2-C6 alkoxyalkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, or 4- to 7-membered heterocyclyl, wherein the cycloalkyl or heterocyclyl is optionally substituted by 1, 2, or 3 halogen, CN, OH, NH2, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylamino, or C1-C6 haloalkyl;
• each R11, R12a, and R12b is independently H, C1-C6 alkyl, C2-C6 alkoxyalkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, or 4- to 7-membered heterocyclyl, wherein the cycloalkyl or heterocyclyl is optionally substituted by 1, 2, or 3 halogen or CN;
• and
• n is 1, 2, or 3;
• provided that the compound does not have the structure:
• or a pharmaceutically acceptable salt thereof.