Inhibitors of lrrk2 kinase
AssigneeHalia Therapeutics, Inc.
InventorsDavid James Bearss, John Sai Keong Kauwe, III, Alexis Henri Abel Mollard
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Abstract
Compounds having activity as inhibitors of LRRK2 kinase are provided. The compounds have Structure (I): or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein A, B, R1a, R1b, R2, and L are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of LRRK2 kinase are also provided.
Claims32
A compound having the following Structure (I):
- or a pharmaceutically acceptable salt, stereoisomer, or prodrug thereof, wherein:
- A is phenylene or 5 or 6-membered heteroarylene;
- B is C3-C8 monocyclic cycloalkyl optionally substituted with one or more substituents selected from amino, halo, hydroxyl, oxo, cyano, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxylalkyl, C1-C6 aminoalkyl, C1-C6 alkylaminylalkyl, C1-C6 alkoxy;
- C1-C6 haloalkoxy, C1-C6 alkylcarbonyl, C1-C6 haloalkylcarbonyl, C1-C6 alkylaminyl, C1-C6 haloalkylaminyl, C1-C6 alkylcarbonylaminyl, C1-C6 haloalkylcarbonylaminyl, C3-C8 cycloalkyl, C3-C8 cycloalkylcarbonyl, C3-C8 halocycloalkylaminyl, and C3-C8 cycloalkylcarbonylaminyl;
- L is a direct bond;
- R1a and R1b are each independently H, halo, cyano, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy or C3-C8 cycloalkyl;
- and
- R2 is 3-8-membered heterocyclyl optionally substituted with one or more substituents selected from halo, cyano, C1-C6 alkyl, hydroxyl, alkoxy, and C1-C6 haloalkyl.
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Dependencies are inferred from the claim text.