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US 2024/0190847 A1Published application
Indoline derivatives as ddr1 and ddr2 inhibitors
AssigneeChiesi Farmaceutici S.p.A.
InventorsLaura CARZANIGA, Fabio RANCATI, Andrea RIZZI, Anna KARAWAJCZYK, Barbara Karolina WOLEK, Toby Matthew Grover MULLINS
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Abstract
The present invention relates to compounds of general formula (I) inhibiting DDR1 and DDR2. Particularly, the invention relates to compounds that are indoline derivatives, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of DDRs, in particular fibrosis.
Claims15
A compound of formula (I)
- wherein
- R1 is H or —(C1-C4)alkyl;
- L is —CH2;
- L1 is selected from the group consisting of —C(O)NH— and —NHC(O)—;
- Hy is a monocyclic heteroaryl optionally substituted by one or more groups selected from —(CH2)nNR4R5, —C(O)NR4R5, —(C1-C4)alkyl, —NR4(CO)R5, —(C1-C4)alkylene-O—(C1-C4)alkyl and —(C4-C7)heterocycloalkyl optionally substituted by one or more groups selected from —(C1-C4)alkyl and oxo;
- n is 0, 1 or 2;
- R4 is H or —(C1-C4)alkyl;
- R5 is H or is selected from the group consisting of (C3-C7)cycloalkyl, —(C1-C4)alkyl and heteroaryl optionally substituted by one or more groups selected from —(C1-C4)alkyl, —(C1-C4)alkylene-NR1R4 and —(C1-C4)alkylene-O—(C1-C4)alkyl;
- X is
- wherein R2 is selected from the group consisting of —(C1-C4)alkyl, —O(C1-C4)haloalkyl, a halogen atoms atom, —(C1-C4)haloalkyl, —(C3-C7)cycloalkyl and —O(C3-C7)cycloalkyl;
- R3 is H or is selected from the group consisting of —O(C1-C4)alkyl, heteroaryl optionally substituted by one or more —(C1-C4)alkyl, and (C4-C7)heterocycloalkyl-(C1-C4)alkylene-, wherein said —(C4-C7)heterocycloalkyl is optionally substituted by one or more groups selected from —(C1-C4)alkyl and —O(C1-C4)alkyl;
- or a pharmaceutically acceptable salt thereof.
9 more elements
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Dependencies are inferred from the claim text.