Substituted quinolinone-8-carbonitrile derivatives having androgen degradation activity and uses thereof

A compound of Formula 1A or Formula 1B, or a tautomer, stereoisomer or a mixture of stereoisomers, or a pharmaceutically acceptable salt, or hydrate, or deuterated derivative thereof:

• wherein:
• R1 is hydrogen, C1-C5 alkyl, C1-C5 halogenated alkyl, or C3-C5 cycloalkyl;
• each R2 is independently hydrogen, C1-C3 alkyl, or C1-C3 haloalkyl;
• X1 is CRa or N;
• X2 is CRb or N;
• X3 is CRc or N;
• X4 is CRd or N;
• each of Ra, Rb, Rc, and Rd is independently hydrogen, halogen, C1-C3 alkyl, C1-C3 haloalkyl, or C1-C3 alkoxy;
• L is a linker of 1 to 15 carbon atoms in length, wherein one or more carbon atoms are optionally substituted with halogen, oxygen, nitrogen, alkylamino, hydroxyl, sulfur, sulfoxide, sulfone, or amide, and wherein one or more carbon atoms are optionally replaced by cycloalkyl, heterocycle, or heteroaryl, wherein the cycloalkyl, heterocycle, or heteroaryl are each independently substituted with 0, 1, or 2 R3;
• each R3 is independently hydrogen, halogen, hydroxyl, C1-C4alkoxyl, C1-C4alkyl, or C1-C4haloalkyl;
• Q is a 1 to 4 carbon atoms in length, wherein one or more carbon atoms are replaced by a heteroaryl, halogen substituted heteroaryl, alkoxy substituted heteroaryl, aryl, halogen substituted aryl, alkoxy substituted aryl, 6,5-membered fused heterocycle, 6,6-membered fused heterocycle, —C(═O), —C(═O)—NH—, or —C(═O)—NH—(C1-C3alkyl), wherein the 6,5-membered fused heterocycle or 6,6-membered fused heterocycle are each independently substituted with 0, 1, or 2 R4;
• and
• R4 is independently hydrogen, halogen, hydroxyl, C1-C3alkyl, C1-C3haloalkyl, C1-C3alkoxy, or an oxo group.