Inhibitors of trek (twik related k+ channels) channel function

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof;
• wherein:
• L is selected from (1) bond, (2) C2-C4-alkynylene, (3) —(C1-C10-alkylene)-O—, (4) —O—(C1-C10-alkylene)-, (5)-(6 to 15 membered aryl)-, (6)-(5 to 15 membered heteroaryl)-, (7)-(3 to 15 membered heterocycle)-, and (8) —(C3-C10-cycloalkane)-;
• W is selected from (1) CH, (2) CR7, and (3) N;
• Z is selected from (1) CH, (2) CR8, and (3) N;
• R7 and R8 are each independently selected from (1) cyano, (2) halogen, (3) pentahalosulfanyl, (4) C1-C10-thioalkyl, (5) C1-C10-alkoxy, (6) C1-C10-alkyl, (7) C2-C10-alkenyl, (8) C2-C10-alkynyl, (9) —OR9, (10) 6 to 15 membered aryl, (11) 5 to 15 membered heteroaryl, (12) C3-C10-cycloalkyl, (13) C2-C10-heteroalkyl, (14) 3 to 15 membered heterocycle, and (15) —(CR10R11)n-Q;
• wherein each of (4)-(8) in R7 or R8 may be optionally substituted with 1 to 10 halogen, and each of (10)-(14) in R7 or R8 may be optionally substituted with 1 to 10 substituents selected from (1) halogen, (2) C1-C10-alkyl, and (3) C1-C10-haloalkyl;
• R9 is selected from (1) hydrogen, (2) C1-C10-alkyl, and (3) C1-C10-haloalkyl;
• R10 is selected from (1) hydrogen, (2) halogen, (3) C1-C10-alkyl, and (4) C1-C10-haloalkyl;
• R11 is selected from (1) hydrogen, (2) halogen, (3) C1-C10-alkyl, and (4) C1-C10-haloalkyl;
• or when R10 and R11 is C1-C10-alkyl, R10 and R11 may optionally form a C3-C10-cycloalkyl together with the carbon atom to which they are attached;
• n is 0, 1, 2, 3 or 4;
• Q is selected from (1) halogen, (2) cyano, (3) —OR101, (4) —SR102, (5) —C(═O)R103, (6) —C(═O)OR104, (7) —S(═O)R105, (8) —SO2R106, (9) —NR107R108, (10) —C(═O)NR109R110, (11) —SO2NR111R112, (12) 6 to 15 membered aryl, (13) 5 to 15 membered heteroaryl, (14) C3-C10-cycloalkyl, and (15) 3 to 15 membered heterocycle, wherein each of (12)-(15) in Q may be optionally substituted with 1 to 10 substituents selected from (1) halogen, (2) C1-C10-alkyl, and (3) C1-C10-haloalkyl;
• R101, R102, R103, R104, R105, R106, R107, R108, R109, R110, R111, and R112 are each independently selected from (1) hydrogen, (2) C1-C10-alkyl, and (3) C1-C10-haloalkyl;
• R6 is selected from (1) hydrogen and (2) —NH2;
• X is selected from (1) CH, (2) CR12, and (3) N;
• R12 is selected from (1) halogen, (2) C1-C10-alkyl and (3) C1-C10-haloalkyl;
• Y is selected from (1) CH, (2) CR13, and (3) N;
• R13 is selected from (1) halogen, (2) C1-C10-alkyl, and (3) C1-C10-haloalkyl;
• R is selected from (1) 6 to 15 membered aryl and (2) 5 to 15 membered heteroaryl, each of which may be optionally substituted with 1 to 5 R14;
• wherein multiple R14 may be the same as or different from each other;
• R14 is selected from (1) halogen, (2) cyano, (3) pentahalosulfanyl, (4) C1-C10-alkyl, (5) C1-C10-thioalkyl, (6) C1-C10-alkoxy, (7) C2-C10-alkenyl, (8) C2-C10-alkynyl, (9) 6 to 15 membered aryl, and (10) —OR9, wherein each of (4)-(9) in R14 may be optionally substituted with 1 to 10 halogen;
• R1 is selected from (1) C1-C10-alkyl, (2) halogen, (3) C1-C10-alkoxy, (4) C1-C10-haloalkyl, (5) C1-C10-haloalkoxy, and (6) cyano;
• R2 is selected from (1) hydrogen, (2) C1-C10-alkyl, (3) halogen, (4) C1-C10-alkoxy, (5) C1-C10-haloalkyl, (6) C1-C10-haloalkoxy, and (7) cyano;
• R3 is selected from (1) hydrogen and (2) C1-C10-alkyl;
• R4 is selected from (1) hydrogen, (2) halogen, (3) C1-C10-alkyl, (4) C1-C10-haloalkyl, (5) cyano, and (6) C3-C10-cycloalkyl which may be optionally substituted with 1 to 10 substituents selected from (1) halogen (2) C1-C10-alkyl and (3) C1-C10-haloalkyl;
• or R3 and R4 may be optionally taken together to form (1) —CR41R42—, (2) —CR43R44—CR45R46—, and (3) —CR47═CR48—;
• R41, R42, R43, R44, R45, R46, R47, and R48 are each independently selected from (1) hydrogen and (2) C1-C10-alkyl;
• R5 is selected from (1) hydrogen, (2) cyano, (3) —NH2, (4) C1-C10-alkyl, (5) C1-C10-alkoxy, (6) —NH—C(═O)—R15, (7) —NH—C(═O)—O—R16, (8) —O—R17, (9) —O—(C1-C10-alkylene)-R18, (10) —C(═O)—R19, (11) —C(═O)—NH—R20, (12) —(C1-C10-alkylene)-(CR21R22)p—R23, (13) 6 to 15 membered aryl, (14) 5 to 15 membered heteroaryl, (15) C3-C10-cycloalkyl, and (16) 3 to 15 membered heterocycle;
• wherein each of (4), (5), (9), and (12) in R5 may be optionally substituted with 1 to 10 substituents selected from (1) halogen, (2) cyano and (3) —OH, and each of (13)-(16) in R5 may be optionally substituted with 1 to 5 R24;
• provided that when R5 is hydrogen, R6 is —NH2;
• R15, R16, R17, R18, R19, and R20 are each independently selected from (1) C1-C10-alkyl, (2) C1-C10-alkoxy, (3) 6 to 15 membered aryl, (4) 5 to 15 membered heteroaryl, (5) C3-C10-cycloalkyl, and (6) 3 to 15 membered heterocycle, wherein each of (1) and (2) in R15, R16, R17, R18, R19, or R20 may be optionally substituted with 1 to 10 substituents selected from (1) halogen, (2) cyano, and (3) —OH, and each of (3)-(6) in R15, R16, R17, R18, R19, or R20 may be optionally substituted with 1 to 5 R25;
• R21 and R22 are each independently selected from (1) hydrogen, (2) halogen, (3) C1-C10-alkyl, and (4) C1-C10-haloalkyl;
• or when R21 and R22 is C1-C10-alkyl, R21 and R22 may optionally form a C3-C10-cycloalkyl together with the carbon atom to which they are attached;
• p is 0, 1, 2, 3, or 4;
• R23 is selected from (1) halogen, (2) cyano, (3) —OR201, (4) —SR202, (5) —C(═O)R203, (6) —C(═O)OR204, (7) —S(═O)R205, (8) —SO2R206, (9) —NR207R208, (10) —C(═O)NR209R210, (11) —SO2NR211R212, (12) 6 to 15 membered aryl, (13) 5 to 15 membered heteroaryl, (14) C3-C10-cycloalkyl, and (15) 3 to 15 membered heterocycle, wherein each of (12)-(15) in R23 may be optionally substituted with 1 to 10 substituents selected from (1) halogen, (2) C1-C10-alkyl and (3) C1-C10-haloalkyl;
• R201, R202, R203, R204, R205, R206, R207, R208, R209, R210, R211, and R212 are each independently selected from (1) hydrogen, (2) C1-C10-alkyl, and (3) C1-C10-haloalkyl;
• R24 and R25 are each independently selected from (1) halogen, (2) cyano, (3) —OH, (4) oxo, (5) C1-C10-alkyl, (6) C1-C10-alkoxy, (7) —(C1-C10-alkylene)-NR26R27, (8) C3-C10-cycloalkyl, (9) 3 to 15 membered heterocycle, and (10) —(C1-C10-alkylene)-(3 to 15 membered heterocycle), wherein each of (5)-(7) in R24 or R25 may be optionally substituted with 1 to 5 substituents selected with (1) halogen, (2) —OH and (3) cyano, and each of (8)-(10) in R24 or R25 may be optionally substituted with 1 to 5 substituents selected with (1) halogen, (2) —OH, (3) cyano, (4) C1-C10-alkyl, and (5) C1-C10-haloalkyl;
• R26 and R27 are each independently selected from (1) hydrogen and (2) C1-C10-alkyl;
• multiple R24 or R25 may be the same as or different from each other.