# US 2024/0189795 A1 · Process for the isolation of amines > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2024/0189795 A1 - Document ID: US20240189795A1 - Status: Published application - Kind: A1 - Application number: 18/284,973 - Filed: 2022-04-21 - Published: 2024-06-13 - Earliest claimed: 2021-04-21 - Assignees: Givaudan SA - Applicants: Givaudan SA - Inventors: Ehsan REYHANITASH; Stephan HAIBER - Web page: https://patentgrep.com/patent/US20240189795A1 ## CPC - B01J 20/261: {obtained by reactions only involving carbon to carbon unsaturated bonds (macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F)} - C07C 209/84: Purification - B01J 20/28026: {Particles within, immobilised, dispersed, entrapped in or on a matrix, e.g. a resin} - B01J 20/3071: {Washing or leaching} - B01J 20/3483: {by thermal treatment not covered by groups B01J20/3441 - B01J20/3475, e.g. by heating or cooling} - C02F 1/285: {using synthetic organic sorbents} - C07C 211/03: Monoamines - C07C 213/10: Separation; Purification; Stabilisation; Use of additives - C12P 13/001: {Amines; Imines} - C07C 209/10: with formation of amino groups bound to carbon atoms of six-membered aromatic rings or from amines having nitrogen atoms bound to carbon atoms of six-membered aromatic rings - C07C 227/38: Separation; Purification; Stabilisation; Use of additives (separation of optical isomers C07C227/34) - B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS - C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS - C02F: TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE (separation in general B01D; special arrangements on waterborne vessels of installations for treating water, waste water or sewage, e.g. for producing fresh water, B63J; adding materials to water to prevent corrosion C23F; treating radioactively-contaminated liquids G21F9/04; regeneration of reactants for recirculation into processes, see the relevant places for the processes) - C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)} ## Abstract There is provided a method for the isolation of an amine from an aqueous solution thereof, comprising the steps of: a) contacting the aqueous solution of the amine with an adsorbent functionalized with carboxyl groups; b) removing water from the adsorbent; and c) thermaly desorbing the amine. The method is particularly suitable for the isolation of ethanolamine. ## Claims ### Claim 1 A method for the isolation of an amine from an aqueous solution thereof, the method comprising: contacting the aqueous solution of the amine with an adsorbent functionalized with carboxyl groups; removing water from the adsorbent; and thermally desorbing the amine. ### Claim 2 (depends on 1) The method of claim 1, wherein the amine is an alkanol amine. ### Claim 3 (depends on 2) The method of claim 2, wherein the alkanol amine is ethanolamine. ### Claim 4 (depends on 1) The method of claim 1, wherein a washing step is added after contacting the aqueous solution of the amine with the adsorbent functionalized with carboxyl groups ### Claim 5 (depends on 1) The method of claim 1, wherein the adsorbent is thermally stable up to at least 150° C. ### Claim 6 (depends on 1) The method of claim 1, wherein the adsorbent has a porous methacrylate matrix. ### Claim 7 (depends on 1) The method of claim 1, wherein the aqueous solution of the amine is a fermentation composition. ### Claim 8 (depends on 1) The method of claim 1, wherein the step of removing water comprises flushing out with a compressed nitrogen stream. ### Claim 9 (depends on 8) The method of claim 8, wherein the compressed nitrogen stream for removing water is heated up to at least 70° C. ### Claim 10 (depends on 8) The method of claim 8, wherein for removing water a container comprising the adsorbent is heated up to at least 80° C. ### Claim 11 (depends on 1) The method of claim 1, wherein the compressed nitrogen stream for thermally desorbing the amine is heated up to at least 100° C. ### Claim 12 (depends on 1) The method of claim 1, wherein for thermally desorbing the amine the container comprising the adsorbent is heated up to at least 120° C. ### Claim 13 (depends on 1) The method of claim 1, wherein the thermally desorbed amine is collected in a cooled condenser. ### Claim 14 (depends on 1) The method of claim 1, wherein the method results in the amine having a purity equal to or greater than about 60%, or greater than about 70%, or greater than about 80%, or greater than about 90%, or greater than about 95%. ### Claim 15 (depends on 1) The method of claim 1, wherein the yield of purified amine is equal to or greater than about 80%, equal to or greater than about 85%, or equal to or greater than about 90%. ### Claim 16 (depends on 3) The method of claim 3, for the isolation of ethanolamine, wherein the method comprises synthesizing ethanolamine by fermenting a carbon source in the presence of an ethanolamine-producing microorganism to provide a fermentation composition comprising ethanolamine. ### Claim 17 (depends on 3) The method of claim 3, wherein a washing step is added after contacting the aqueous solution of the amine with the adsorbent functionalized with carboxyl groups ### Claim 18 (depends on 3) The method of claim 3, wherein the adsorbent is thermally stable up to at least 150° C. ### Claim 19 (depends on 3) The method of claim 3, wherein the adsorbent has a porous methacrylate matrix. ### Claim 20 (depends on 3) The method of claim 3, wherein the aqueous solution of the amine is a fermentation composition.