# US 2024/0189613 A1 · Use Of Cold Atmospheric Pressure Plasma To Treat Warts

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- Number: US 2024/0189613 A1
- Document ID: US20240189613A1
- Status: Published application
- Kind: A1
- Application number: 18/486,722
- Filed: 2023-10-13
- Published: 2024-06-13
- Earliest claimed: 2018-06-29
- Assignees: Drexel University
- Applicants: Drexel University
- Inventors: Peter C. Friedman; Vandana Miller; Gregory Fridman; Abraham Lin; Alexander Fridman
- Web page: https://patentgrep.com/patent/US20240189613A1

## CPC

- A61B 18/00: Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body (eye surgery A61F9/007; ear surgery A61F11/00)
- A61N 1/44: Applying ionised fluids {(ion generators H01J37/00)}
- A61N 1/08: Arrangements or circuits for monitoring, protecting, controlling or indicating {(for external stimulators A61N1/3603; for implantable neurostimulators A61N1/36128; for heart stimulators A61N1/37; for defibrillators A61N1/3925)}
- A61B 2017/00172: {Pulse trains, bursts, intermittent continuous operation}
- A61B 2018/0047: {Upper parts of the skin, e.g. skin peeling or treatment of wrinkles}
- A61B 2018/00583: {Coblation, i.e. ablation using a cold plasma}
- A61B 2018/00702: {Power or energy}
- A61B 2018/00726: {Duty cycle}
- A61B 2018/00732: {Frequency}
- A61B 2018/00761: {Duration}
- A61N 1/0468: {Specially adapted for promoting wound healing}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

A method for treating a wart on skin of a patient includes guiding non-thermal, atmospheric pressure plasma over areas of the tissue having the wart for a length of time effective to give rise to an at least partial amelioration of the wart.

## Claims

### Claim 1

A method for treating a wart on skin of a patient, the method comprising:
with a device that comprises
(i) a high voltage electrode,
(ii) an insulating or semiconducting barrier,
(iii) a power source capable of providing a voltage,
(iv) a pulse generator, and
(v) a second electrode, a ground, or both,
applying non-thermal, atmospheric pressure plasma over an area of tissue having the wart under conditions sufficient to give rise to an at least partial reduction in size of the wart,
the non-thermal atmospheric plasma being generated by a high frequency oscillation of the high voltage of from about 5 to about 20,000 kHz.

### Claim 2 (depends on 1)

The method of claim 1, wherein the conditions sufficient to give rise to an at least partial reduction in size of the wart is to apply the non-thermal plasma to the tissue having the wart for at least one period of time lasting between about 10 seconds and about 10 minutes.

### Claim 3 (depends on 2)

The method of claim 2, wherein the non-thermal plasma is applied between 1 and 5 times.

### Claim 4 (depends on 1)

The method of claim 1, wherein the non-thermal plasma is delivered with a power in a range of from about 10 kV to about 50 kV.

### Claim 5 (depends on 4)

The method of claim 4, wherein the power is about 20 kV.

### Claim 6 (depends on 1)

The method of claim 1, wherein the non-thermal plasma is delivered with a frequency in a range of from about 50 Hz to about 3500 Hz.

### Claim 7 (depends on 6)

The method of claim 6, wherein the frequency is about 400 Hz.

### Claim 8 (depends on 1)

The method of claim 1, wherein the non-thermal plasma is delivered with a pulse having a duration in a range of from about 100 ps to about 500 ns.

### Claim 9 (depends on 8)

The method of claim 8, wherein the pulse duration is about 20 ns.