# US 2024/0189588 A1 · Systems and methods for implantable electrical stimulation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2024/0189588 A1 - Document ID: US20240189588A1 - Status: Published application - Kind: A1 - Application number: 18/556,345 - Filed: 2022-04-19 - Published: 2024-06-13 - Earliest claimed: 2021-04-19 - Applicants: The Brigham and Women's Hospital, Inc.; Northeastern University - Inventors: David J. Segar; Sumientra Rampersad; Joshua D. Bernstock - Web page: https://patentgrep.com/patent/US20240189588A1 ## CPC - A61N 1/36002: {Cancer treatment, e.g. tumour} - A61B 17/70: Spinal positioners or stabilisers, e.g. stabilisers comprising fluid filler in an implant - A61B 17/86: Pins or screws {or threaded wires; nuts therefor (A61B17/72 take precedence)} - A61B 17/866: {Material or manufacture} - A61N 1/0551: {Spinal or peripheral nerve electrodes} - A61N 1/0558: {Anchoring or fixation means therefor} - A61N 1/36062: {Spinal stimulation} - A61N 1/36157: {Current (A61N1/3616 takes precedence)} - A61N 1/37518: {Anchoring of the implants, e.g. fixation} - A61N 1/378: Electrical supply - A61B 17/863: {with thread interrupted or changing its form along shank, other than constant taper} - A61N 1/403: {for thermotherapy, e.g. hyperthermia} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract In accordance with one aspect of the disclosure, a system including a plurality of pedicle screws configured to engage a spine of a patient and each including an electrode, a power source coupled to the pedicle screws and configured to provide an electrical current to each electrode, and a controller is provided. The controller is configured to selectively supply power to the pedicle screws to cause a first electrical stimulation to be output in a first direction from a first pedicle screw to a second pedicle screw, and cause a second, electrical stimulation to be output in a second direction from the second pedicle screw to the first pedicle screw. ## Claims ### Claim 1 A system comprising: a plurality of pedicle screws configured to engage a spine of a patient and each comprising an electrode; a power source coupled to the pedicle screws and configured to provide an electrical current to each electrode; and a controller configured to selectively supply power to the pedicle screws to: cause a first electrical stimulation to be output in a first direction from a first pedicle screw to a second pedicle screw; and cause a second electrical stimulation to be output in a second direction from the second pedicle screw to the first pedicle screw. ### Claim 2 (depends on 1) The system of claim 1, wherein the first pedicle screw is configured to be coupled to a first vertebra, the second pedicle screw is configured to be coupled to a second vertebra, and the first electrical stimulation is directed across the first vertebra. ### Claim 3 (depends on 2) The system of claim 2, wherein the plurality of pedicle screws comprises a third pedicle screw configured to be coupled to a perispinal region of the patient and a fourth pedicle screw configured to be coupled to the perispinal region. ### Claim 4 (depends on 3) The system of claim 3, wherein the controller is further configured to selectively supply power to the plurality of pedicle screws to: cause a third electrical stimulation to be output in a third direction from the first pedicle screw to the third pedicle screw to stimulate the perispinal region; or cause a fourth electrical stimulation to be output in a fourth direction from the second pedicle screw to the fourth pedicle screw to stimulate the perispinal region. ### Claim 5 (depends on 1) The system of claim 1, wherein the first pedicle screw is configured to be coupled to a first vertebra, the second pedicle screw is configured to be coupled to a different location within the first vertebra. ### Claim 6 (depends on 1) The system of claim 1, wherein the plurality of pedicle screws comprises a third pedicle screw and a fourth pedicle screw, the first pedicle screw is coupled to a first pedicle in a first vertebra of the spine of the patient, the third pedicle screw is coupled to a second pedicle in the first vertebra, the second pedicle screw is coupled to a first pedicle in a second vertebra of the spine of the patient, and the fourth pedicle screw is coupled to a second pedicle in the second vertebra. ### Claim 7 (depends on 6) The system of claim 6, wherein the first electrical stimulation and the second electrical stimulation are delivered across the first vertebra, and the controller is further configured to selectively supply power to the third pedicle screw and the fourth pedicle screw to: cause a third electrical stimulation to be output in a third direction from the third pedicle screw to the fourth pedicle screw to stimulate a patient spinal cord; or cause a fourth electrical stimulation to be output in a fourth direction from the fourth pedicle screw to the third pedicle screw to stimulate the patient spinal cord. ### Claim 8 (depends on 1) The system of claim 1, wherein the first pedicle screw comprises a first electrode having a substantially smooth surface angularly extending across no more than ninety degrees of an outer surface of the first pedicle screw or the second pedicle screw comprises a second electrode having a substantially flat surface angularly extending across no more than ninety degrees of an outer surface of the second pedicle screw. ### Claim 9 A system comprising: a first implant device configured to engage a spine of a patient and comprising a first electrode; a second implant device configured to engage the spine of the patient and comprising a second electrode; a power source coupled to the first implant device and the second implant device and configured to provide an electrical current to the first electrode and the second electrode; and a controller configured to selectively supply power to the first implant device and the second implant device to: cause a first electrical stimulation to be output in a first direction from the first implant device to the second implant device; and cause a second electrical stimulation to be output in a second direction from the first implant device to the second implant device. ### Claim 10 (depends on 9) The system of claim 9, wherein the first electrode comprises a substantially smooth surface angularly extending across ninety degrees or less of an outer surface of the first implant device. ### Claim 11 (depends on 10) The system of claim 10, wherein the first electrode comprises an electrically conductive metal arranged along a length of the first implant device, and wherein the first electrode is distanced away from a distal end of the first implant device. ### Claim 12 (depends on 9) The system of claim 9, wherein the first electrical stimulation and the second electrical stimulation are configured to treat at least one of a spinal tumor, an intramedullary tumor, an extramedullary tumor, an intradural tumor, an extradural tumor, a perispinal tumor, and/or a nerve root tumor. ### Claim 13 (depends on 9) The system of claim 9, wherein the first implant device is further configured to be secured to a perispinal region of the patient. ### Claim 14 (depends on 9) The system of claim 9, wherein an outer surface of the first implant device comprises an outer surface of the first electrode and a nonconductive material. ### Claim 15 A system comprising: a screw comprising an electrode and a threading configured to secure the screw with the electrode in a fixed position in a patient; a power source coupled to the screw; and a controller configured to control operation of the power source to selectively deliver an electrical current from the electrode or receive an electrical current with the screw to effectuate a therapeutic plan. ### Claim 16 (depends on 15) The system of claim 15, wherein the power source and the controller operate in concert to carry out the therapeutic plan by deliver the electrical current with parameters selected to treat a tumor in the patient. ### Claim 17 (depends on 16) The system of claim 16, wherein the tumor is at least partially located in a spinal cord of the patient. ### Claim 18 (depends on 16) The system of claim 16, wherein the tumor is at least partially located in a perispinal region of the patient. ### Claim 19 (depends on 15) The system of claim 15, wherein the therapeutic plan comprises providing the electrical current along a length of a spinal cord of the patient. ### Claim 20 (depends on 15) The system of claim 15, wherein the therapeutic plan comprises providing the electrical current across a length of a spinal cord of the patient. ### Claim 21 (depends on 15) The system of claim 15, wherein the screw is configured to at least one of provide or receive electrical currents with at least two other screws secured in the patient.