# US 2024/0189488 A1 · Medical device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2024/0189488 A1 - Document ID: US20240189488A1 - Status: Published application - Kind: A1 - Application number: 18/554,163 - Filed: 2022-04-07 - Published: 2024-06-13 - Earliest claimed: 2021-04-08 - Assignees: Shanghai Microport Medical (Group) Co., Ltd. - Applicants: Shanghai Microport Medical (Group) Co., Ltd. - Inventors: Jiaojiao WANG; Can SUN; Qi ZHOU; Yao YAO; Junfei LI - Web page: https://patentgrep.com/patent/US20240189488A1 ## CPC - A61L 31/088: {Other specific inorganic materials not covered by A61L31/084 or A61L31/086} - C23C 28/32: {including at least one pure metallic layer} - A61L 31/022: {Metals or alloys} - A61L 31/14: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - C23C 4/02: Pretreatment of the material to be coated, e.g. for coating on selected surface areas - C23C 4/06: Metallic material - C23C 4/08: containing only metal elements (C23C4/073 takes precedence) - C23C 4/10: Oxides, borides, carbides, nitrides or silicides; Mixtures thereof - C23C 4/11: Oxides - C23C 4/18: After-treatment - C23C 22/48: not containing phosphates, hexavalent chromium compounds, fluorides or complex fluorides, molybdates, tungstates, vanadates or oxalates - C23C 28/321: {with at least one metal alloy layer} - C23C 28/322: {only coatings of metal elements only} - C23C 28/34: {including at least one inorganic non-metallic material layer, e.g. metal carbide, nitride, boride, silicide layer and their mixtures, enamels, phosphates and sulphates} - C23C 28/341: {with at least one carbide layer} - C23C 28/345: {with at least one oxide layer} - A61L 2420/02: Methods for coating medical devices - A61L 2420/06: Coatings containing a mixture of two or more compounds - A61L 2420/08: Coatings comprising two or more layers - C25D 7/0607: {Wires} - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - C23C: COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL (making metal-coated products by extrusion B21C23/22; covering with metal by connecting pre-existing layers to articles, see the relevant places, e.g. B21D39/00, B23K; metallising of glass C03C; metallising mortars, concrete, artificial stone, ceramics or natural stone C04B41/00; enamelling of, or applying a vitreous layer to, metals C23D; treating metal surfaces or coating of metals by electrolysis or electrophoresis C25D; single-crystal film growth C30B; by metallising textiles D06M11/83; decorating textiles by locally metallising D06Q1/04) - C25D: PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR ## Abstract The present disclosure relates to a medical device. The medical device comprises a matrix and a first coating coated on the matrix. The matrix contains a metal element X having a content of ≥5 wt %; the first coating is at least one of an elemental metal layer of the metal element X, an alloy layer of the metal element X, and a metal-ceramic layer of the metal element X; and the first coating does not contain nickel and cobalt. The medical device has good use safety, reliability, and biocompatibility, so that a product can meet a use requirement of large plastic deformation, and has good reliability during use. The medical device can particularly meet requirements of product with large plastic deformation during use, such as medical implant devices. ## Claims ### Claim 1 A medical device, comprising a substrate and a first coating wrapping the substrate, wherein the substrate contains a metal element X with a content of ≥5 wt %, the first coating comprises at least one of an elemental metal layer of the metal element X, an alloy layer of the metal element X, and a metal-ceramic layer of the metal element X, and the first coating does not contain nickel and cobalt. ### Claim 2 (depends on 1) The medical device according to claim 1, wherein the first coating is a stack layer formed by the elemental metal layer and at least one of the alloy layer and the metal-ceramic layer; in the first coating, the elemental metal layer is an inner layer close to the substrate, at least one of the alloy layer and the metal-ceramic layer is an outer layer away from the substrate. ### Claim 3 (depends on 1) The medical device according to claim 1, wherein the elemental metal layer is a passivated metal coating when the first coating is the elemental metal layer of the metal element X. ### Claim 4 (depends on 1) The medical device according to claim 1, wherein the elemental metal layer is located between the substrate and the metal-ceramic layer when the first coating is the stack layer formed by the elemental metal layer and the metal-ceramic layer. ### Claim 5 (depends on 1) The medical device according to claim 1, wherein the elemental metal layer is located between the substrate and the alloy layer when the first coating is the stack layer formed by the elemental metal layer and the alloy layer. ### Claim 6 (depends on 1) The medical device according to claim 1, wherein a material of the metal-ceramic layer is at least one of oxide, carbide, nitride, silicide, and boride of the metal element X. ### Claim 7 (depends on 1) The medical device according to claim 1, wherein the metal element X is Cr, W, Mo or any one of noble metal element. ### Claim 8 (depends on 1) The medical device according to claim 1, wherein the content of the metal element X in the substrate ranges from 7 wt % to 60 wt %. ### Claim 9 (depends on 1) The medical device according to claim 1, wherein the substrate is a substrate capable of plastic deformation. ### Claim 10 (depends on 1) The medical device according to claim 1, wherein a material of the substrate is selected from the group consisting of stainless steel, cobalt-based alloy, titanium alloy, noble metal alloy, and nickel-titanium shape memory alloy. ### Claim 11 (depends on 1) The medical device according to claim 1, wherein the metal element X is one of Cr, W, Mo or Pt. ### Claim 12 (depends on 1) The medical device according to claim 1, wherein the first coating contains the metal-ceramic layer, the medical device further comprises a second coating provided on the metal-ceramic layer; wherein the metal-ceramic layer is a carbide of the metal element X, and the second coating is a carbon layer. ### Claim 13 (depends on 1) The medical device according to claim 1, wherein the first coating contains the metal-ceramic layer, the medical device further comprises a second coating provided on the metal-ceramic layer; wherein the metal-ceramic layer is a silicide of the metal element X, and the second coating is a silicon layer. ### Claim 14 (depends on 1) The medical device according to claim 1, wherein a difference of self-corrosion potential between any two adjacent layers of layer structures with different materials of the medical device is within 100 mV. ### Claim 15 (depends on 1) The medical device according to claim 1, wherein thicknesses of the elemental metal layer, the alloy layer, and the metal-ceramic layer range from 10 nm to 500 nm. ### Claim 16 (depends on 1) The medical device according to claim 1, wherein the metal element X is not element titanium. ### Claim 17 (depends on 1) The medical device according to claim 1, further comprising a medicine active layer located on a surface of the first coating. ### Claim 18 (depends on 17) The medical device according to claim 17, wherein the first coating is formed with a medicine-carrying recess, and the medicine active layer is located within the medicine-carrying recess.