# US 2024/0189480 A1 · Polyphenol coating and preparation method and use thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2024/0189480 A1 - Document ID: US20240189480A1 - Status: Published application - Kind: A1 - Application number: 18/295,378 - Filed: 2023-04-04 - Published: 2024-06-13 - Earliest claimed: 2022-12-12 - Applicants: Anhui Medical University - Inventors: Hua QIU; Zhaojia LIANG; Quanli LI; Zirui CHEN; Jialong CHEN; Xiangyang LI; Shuang TAN - Web page: https://patentgrep.com/patent/US20240189480A1 ## CPC - A61L 27/3637: {characterised by the origin of the biological material other than human or animal, e.g. plant extracts, algae} - A61L 27/34: Macromolecular materials - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 29/085: {Macromolecular materials} - A61L 29/16: Biologically active materials, e.g. therapeutic substances {(A61L29/048 takes precedence)} - A61L 31/10: Macromolecular materials - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents - A61L 2420/02: Methods for coating medical devices - A61L 2420/06: Coatings containing a mixture of two or more compounds - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract The present disclosure relates to the technical field of coatings. In order to prepare a polyphenol coating more efficiently and gently on the surface of a material, the present disclosure provides a preparation method of a polyphenol coating, including the following steps: (1) preparing a Tanfloc aqueous solution; (2) adjusting the Tanfloc aqueous solution obtained in step (1) to be in a colloidal suspension state to obtain a modified solution; and (3) placing a carrier material in the modified solution prepared in step (2) to obtain a modified coating on a surface of the carrier material. In the present disclosure, by the preparation method of a polyphenol coating, the polyphenol coating can be efficiently prepared on a material surface under mild conditions. ## Claims ### Claim 1 A preparation method of a polyphenol coating, comprising the following steps: (1) preparing a Tanfloc aqueous solution; (2) adjusting the Tanfloc aqueous solution obtained in step (1) to be in a colloidal suspension state to obtain a modified solution; and (3) placing a carrier material in the modified solution prepared in step (2) to obtain a modified coating on a surface of the carrier material. ### Claim 2 (depends on 1) The preparation method of a polyphenol coating according to claim 1, wherein in step (2), the Tanfloc aqueous solution is adjusted with an alkaline solution, such that the modified solution is at a pH value of 5.5 to 8.5. ### Claim 3 (depends on 1) The preparation method of a polyphenol coating according to claim 1, wherein in step (2), the Tanfloc aqueous solution is treated with a salt solution, such that the Tanfloc aqueous solution forms a colloid. ### Claim 4 (depends on 1) The preparation method of a polyphenol coating according to claim 1, wherein in step (3), the carrier material is immersed in the modified solution for greater than or equal to 1 min. ### Claim 5 (depends on 1) The preparation method of a polyphenol coating according to claim 1, wherein in step (3), when the carrier material is placed in the modified solution, the modified solution is in an ultrasonic or vibrating environment. ### Claim 6 (depends on 1) The preparation method of a polyphenol coating according to claim 1, wherein in step (1), the Tanfloc aqueous solution has 0.05 mg/ml to 20 mg/ml of Tanfloc. ### Claim 7 (depends on 1) A polyphenol coating prepared by the preparation method of a polyphenol coating according to claim 1. ### Claim 8 (depends on 7) The polyphenol coating according to claim 7, wherein in step (2), the Tanfloc aqueous solution is adjusted with an alkaline solution, such that the modified solution is at a pH value of 5.5 to 8.5. ### Claim 9 (depends on 7) The polyphenol coating according to claim 7, wherein in step (2), the Tanfloc aqueous solution is treated with a salt solution, such that the Tanfloc aqueous solution forms a colloid. ### Claim 10 (depends on 7) The polyphenol coating according to claim 7, wherein in step (3), the carrier material is immersed in the modified solution for greater than or equal to 1 min. ### Claim 11 (depends on 7) The polyphenol coating according to claim 7, wherein in step (3), when the carrier material is placed in the modified solution, the modified solution is in an ultrasonic or vibrating environment. ### Claim 12 (depends on 7) The polyphenol coating according to claim 7, wherein in step (1), the Tanfloc aqueous solution has 0.05 mg/ml to 20 mg/ml of Tanfloc. ### Claim 13 (depends on 1) A method for surface modification of a medical material using the preparation method of a polyphenol coating according to claim 1. ### Claim 14 (depends on 13) The method according to claim 13, wherein in step (2), the Tanfloc aqueous solution is adjusted with an alkaline solution, such that the modified solution is at a pH value of 5.5 to 8.5. ### Claim 15 (depends on 13) The method according to claim 13, wherein in step (2), the Tanfloc aqueous solution is treated with a salt solution, such that the Tanfloc aqueous solution forms a colloid. ### Claim 16 (depends on 13) The method according to claim 13, wherein in step (3), the carrier material is immersed in the modified solution for greater than or equal to 1 min. ### Claim 17 (depends on 13) The method according to claim 13, wherein in step (3), when the carrier material is placed in the modified solution, the modified solution is in an ultrasonic or vibrating environment. ### Claim 18 (depends on 13) The method according to claim 13, wherein in step (1), the Tanfloc aqueous solution has 0.05 mg/ml to 20 mg/ml of Tanfloc.