Targeted Therapeutic Lipid Nanoparticles and Methods of Use
AssigneeThe Trustees of the University of Pennsylvania
InventorsOscar Marcos Contreras, Patrick Glassman, Jia Nong, Jacob Brenner, Vladimir Muzykantov, Drew Weissman
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Abstract
The present invention relates to compositions comprising a delivery vehicle for delivery of a therapeutic agent for the treatment of a neurological disorder conjugated to a targeting domain, wherein the targeting domain specifically binds to an endothelial marker. The invention also relates to methods of treating or preventing neurological conditions using the described compositions.
Claims26
A composition comprising a delivery vehicle conjugated to a targeting domain, wherein the delivery vehicle comprises at least one therapeutic agent for the treatment of a stroke or a neurological condition, and wherein the targeting domain specifically binds to an endothelial marker of the vasculature, wherein the marker is selected from the group consisting of ICAM-1, PECAM-1, VCAM-1, ACE, APP, PV1, P-selectin, E-selectin, and VE-cadherin.
Dependencies are inferred from the claim text.