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US 2024/0189435 A1Published application
Novel peptide-oligonucleotide conjugate and use thereof
AssigneeKorea Institute of Science and Technology
InventorsYoo Soo YANG, Sun Hwa KIM, Ick Chan KWON, Eun Hye KIM
Life of this patent
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Abstract
Disclosed is an agent capable of inhibiting the activity or enhancing expression of various cancer-related RNAs in TAMS and cancer cells. Disclosed is also a dual-targeted drug delivery system capable of binding to both tumor cells and macrophages in which the PD-L1 receptor is overexpressed.
Claims34
A peptide-oligonucleotide conjugate,
- wherein the peptide is a PD-L1-binding peptide, and
- the oligonucleotide is an oligonucleotide or a modified oligonucleotide thereof.
Dependencies are inferred from the claim text.