# US 2024/0189366 A1 · Bioeffective krill oil compositions

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- Number: US 2024/0189366 A1
- Document ID: US20240189366A1
- Status: Published application
- Kind: A1
- Application number: 18/541,250
- Filed: 2023-12-15
- Published: 2024-06-13
- Earliest claimed: 2007-03-28
- Assignees: Aker Biomarine Human Ingredients AS
- Applicants: Aker BioMarine Human Ingredients AS
- Inventors: Inge Bruheim; Snorre Tilseth; Daniele Mancinelli
- Web page: https://patentgrep.com/patent/US20240189366A1

## CPC

- A61K 35/612: Crustaceans, e.g. crabs, lobsters, shrimps, krill or crayfish; Barnacles
- A23L 33/115: Fatty acids or derivatives thereof; Fats or oils
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 9/48: Preparations in capsules, e.g. of gelatin, of chocolate {(A61K9/0004 takes precedence; bite capsules A61K9/0056)}
- A61K 9/4825: {Proteins, e.g. gelatin (gelatin capsule shells with substantial amounts of other macromolecular substances A61K9/4816)}
- A61K 9/4858: {Organic compounds}
- A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K 31/20: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K 31/202: having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557)
- A61K 31/215: of carboxylic acids
- A61K 31/23: of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K 31/235: having an aromatic ring attached to a carboxyl group
- A61K 31/575: substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A61K 31/683: Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K 31/685: one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- C11B 3/006: {by extraction}
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C11B: PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES (drying-oils C09F)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO2 or CO2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

## Claims

### Claim at position 1

1-90. (canceled)

### Claim 91

A krill meal composition comprising less than about 200 g/kg total fat.

### Claim 92 (depends on 91)

The krill meal composition of claim 91 comprising from about 5 to about 100 mg/kg astaxanthin esters.

### Claim 93 (depends on 91)

The krill meal composition of claim 91, comprising greater than about 65% protein.

### Claim 94 (depends on 91)

The krill meal composition of any one of claim 91, comprising greater than about 70% protein.

### Claim 95 (depends on 91)

A food product comprising the krill meal of claim 91.

### Claim 96 (depends on 95)

The food product of claim 95, wherein the food product is an animal feed.

### Claim 97 (depends on 91)

A method of supplementing the diet of a subject in need thereof comprising orally administering the krill meal composition of claim 91 to the subject.

### Claim 98 (depends on 97)

The method of claim 97, wherein the subject is an aquatic animal.

### Claim 99 (depends on 98)

The method of claim 98, wherein the administration of the krill meal composition increases flesh coloration in the aquatic animal.

### Claim 100 (depends on 98)

The method of claim 98, wherein the administration of the krill meal composition increases growth and overall survival rate of the aquatic animal.