Back to results
US 2024/0189333 A1Published application
Phospholipid compounds and formulations
AssigneeApplaud Medical, Inc.
InventorsDaniel J. LASER, Alice LUONG, Robert G. MIOTKE
Life of this patent
Estimating the term…
Abstract
The present disclosure provides phospholipid-containing compounds, pharmaceutical compositions and microspheres that exhibit high affinity for mineralized metals. The present disclosure also provides strategies for using said compounds, compositions and microspheres in the treatment of nephrolithiasis or kidney stone disease, and methods of manufacturing and preparing said compounds and compositions.
Claims174
A compound of Formula IV
- or a salt, isomer, or salt of an isomer thereof, wherein:
- p is from 10 to 30;
- q is from 1 to 100;
- C is selected from the group consisting of:
- B is selected from the group consisting of:
- a covalent bond and an ethyl group;
- A is selected from the group consisting of:
- a covalent bond, acyl, acylamino, aminoacyl, acyloxy, thioacyl, aminocarbonyl, aminoacyl carbonyloxy, aminothiocarbonyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aminosulfonyloxy, aminosulfonylamino, aminosulfonyl, amidino, and carboxy ester;
- and
- X is selected from the group consisting of:
- hydrogen, silyl, acyl, aminoacyl, thioacyl, aminocarbonyl, aminoacyl carbonyloxy, aminothiocarbonyl, aminosulfonyl, amidino, substituted sulfonyl, substituted sulfinyl, carboxy ester, phthalimido, SO3H and PO3H.
8 more elements
A pharmaceutical composition, comprising:
- a compound of Formula IV
- or a pharmaceutically acceptable salt, isomer, or salt of an isomer thereof;
- wherein:
- p is from 10 to 30,
- q is front 1 to 100,
- C is selected from the group consisting of:
- B is selected from the group consisting of:
- a covalent bond and an ethyl group;
- A is selected from the group consisting of:
- a covalent bond, acyl, acylamino, aminoacyl, acyloxy, thioacyl, aminocarbonyl, aminoacyl carbonyloxy, aminothiocarbonyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aminosulfonyloxy, aminosulfonylamino, aminosulfonyl, amidino, and carboxy ester;
- and
- X is selected from the group consisting of:
- hydrogen, silyl, acyl, aminoacyl, thioacyl, aminocarbonyl, aminoacyl carbonyloxy, aminothiocarbonyl, aminosulfonyl, amidino, substituted sulfonyl, substituted sulfinyl, carboxy ester, phthalimido, OH SO3H and PO3H.
10 more elements
A method of manufacturing microspheres, the method comprising:
- (f) preparing a formulation for making microspheres comprising:
- a compound of Formula I
- or a salt, isomer, or salt of an isomer thereof,
- a compound of Formula II
- or a salt, isomer, or salt of an isomer thereof;
- a compound of Formula III
- or a salt, isomer, or salt of an isomer thereof;
- optionally, at least one pharmaceutically acceptable excipient;
- and
- water,
- wherein:
- n is from 10 to 30,
- m is from 1 to 100,
- t is from 10 to 30,
- y is from 1 to 100,
- z is from 10 to 30, and
- X is selected from the group consisting of:
- hydrogen, silyl, acyl, aminoacyl, thioacyl, aminocarbonyl, aminoacyl carbonyloxy, aminothiocarbonyl, aminosulfonyl, amidino, substituted sulfonyl, substituted sulfinyl, carboxy ester, phthalimido, OH, SO3H and PO3H.
15 more elements
Dependencies are inferred from the claim text.